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Arginine-dependent immune responses.
Martí I Líndez, Adrià-Arnau; Reith, Walter.
Afiliação
  • Martí I Líndez AA; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. adria-arnau.marti@unige.ch.
  • Reith W; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Cell Mol Life Sci ; 78(13): 5303-5324, 2021 Jul.
Article em En | MEDLINE | ID: mdl-34037806
A growing body of evidence indicates that, over the course of evolution of the immune system, arginine has been selected as a node for the regulation of immune responses. An appropriate supply of arginine has long been associated with the improvement of immune responses. In addition to being a building block for protein synthesis, arginine serves as a substrate for distinct metabolic pathways that profoundly affect immune cell biology; especially macrophage, dendritic cell and T cell immunobiology. Arginine availability, synthesis, and catabolism are highly interrelated aspects of immune responses and their fine-tuning can dictate divergent pro-inflammatory or anti-inflammatory immune outcomes. Here, we review the organismal pathways of arginine metabolism in humans and rodents, as essential modulators of the availability of this semi-essential amino acid for immune cells. We subsequently review well-established and novel findings on the functional impact of arginine biosynthetic and catabolic pathways on the main immune cell lineages. Finally, as arginine has emerged as a molecule impacting on a plethora of immune functions, we integrate key notions on how the disruption or perversion of arginine metabolism is implicated in pathologies ranging from infectious diseases to autoimmunity and cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Doenças Transmissíveis / Imunidade / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Doenças Transmissíveis / Imunidade / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article