Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/ß-catenin pathway.

Li, Yongmei; Zhao, Zean; Luo, Jian; Jiang, Yanqing; Li, Lu; Chen, Yanyu; Zhang, Leqi; Huang, Qinghua; Cao, Ying; Zhou, Pingzheng; Wu, Ting; Pang, Jianxin

Li, Yongmei; Zhao, Zean; Luo, Jian; Jiang, Yanqing; Li, Lu; Chen, Yanyu; Zhang, Leqi; Huang, Qinghua; Cao, Ying; Zhou, Pingzheng; Wu, Ting; Pang, Jianxin.

Afiliação

Li Y; Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Zhao Z; Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Luo J; Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Jiang Y; Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Li L; Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Chen Y; Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Zhang L; Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Huang Q; Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Cao Y; Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Zhou P; Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Wu T; Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Pang J; Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, China. Electronic address: pjx@smu.edu.cn.

Phytomedicine ; 87: 153585, 2021 Jul.

Article em En | MEDLINE | ID: mdl-34044255

Assuntos

Apigenina/farmacologia; Proteínas Facilitadoras de Transporte de Glucose/antagonistas & inibidores; Hiperuricemia/tratamento farmacológico; Nefropatias/tratamento farmacológico; Transportadores de Ânions Orgânicos/antagonistas & inibidores; Animais; Apigenina/administração & dosagem; Creatinina/sangue; Relação Dose-Resposta a Droga; Fibrose; Proteínas Facilitadoras de Transporte de Glucose/genética; Proteínas Facilitadoras de Transporte de Glucose/metabolismo; Células HEK293; Humanos; Hiperuricemia/induzido quimicamente; Hiperuricemia/fisiopatologia; Nefropatias/metabolismo; Nefropatias/patologia; Masculino; Camundongos; Nefrite/tratamento farmacológico; Nefrite/patologia; Transportadores de Ânions Orgânicos/genética; Transportadores de Ânions Orgânicos/metabolismo; Ácido Oxônico/toxicidade; Ácido Úrico/sangue; Ácido Úrico/metabolismo; Via de Sinalização Wnt/efeitos dos fármacos; beta Catenina/metabolismo

Palavras-chave

Apigenin (API); Glucose transporter 9 (GLUT9); Hyperuricemic nephropathy (HN); Urate transporter 1 (URAT1)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transportadores de Ânions Orgânicos / Hiperuricemia / Apigenina / Proteínas Facilitadoras de Transporte de Glucose / Nefropatias Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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