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Copper-catalyzed sulfonylation of N-tosylhydrazones followed by a one-pot C-N bond formation.
Zhang, Kena; Provot, Olivier; Tran, Christine; Alami, Mouad; Hamze, Abdallah.
Afiliação
  • Zhang K; Université Paris-Saclay, BioCIS, Faculté de Pharmacie, CNRS, 92290 Châtenay-Malabry, France. abdallah.hamze@universite-paris-saclay.fr.
  • Provot O; Université Paris-Saclay, BioCIS, Faculté de Pharmacie, CNRS, 92290 Châtenay-Malabry, France. abdallah.hamze@universite-paris-saclay.fr.
  • Tran C; Université Paris-Saclay, BioCIS, Faculté de Pharmacie, CNRS, 92290 Châtenay-Malabry, France. abdallah.hamze@universite-paris-saclay.fr.
  • Alami M; Université Paris-Saclay, BioCIS, Faculté de Pharmacie, CNRS, 92290 Châtenay-Malabry, France. abdallah.hamze@universite-paris-saclay.fr.
  • Hamze A; Université Paris-Saclay, BioCIS, Faculté de Pharmacie, CNRS, 92290 Châtenay-Malabry, France. abdallah.hamze@universite-paris-saclay.fr.
Org Biomol Chem ; 19(24): 5358-5367, 2021 06 28.
Article em En | MEDLINE | ID: mdl-34047324
A new methodology to synthesize sulfonyl-N-phenylaniline derivatives via the trapping of bromo-sulfone derivatives generated from N-tosylhydrazones (NTHs) with amines is described. The reaction proved successful for a wide range of NTHs and amines and tolerated various functional groups on either coupling partner (35 examples). The mechanism was studied, and we showed that the sulfone formation does not follow a radical pathway.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article