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Intrathecal Immunoglobulin M Synthesis is an Independent Biomarker for Higher Disease Activity and Severity in Multiple Sclerosis.
Oechtering, Johanna; Schaedelin, Sabine; Benkert, Pascal; Müller, Stefanie; Achtnichts, Lutz; Vehoff, Jochen; Disanto, Giulio; Findling, Oliver; Fischer-Barnicol, Bettina; Orleth, Annette; Chan, Andrew; Pot, Caroline; Barakovic, Muhamed; Rahmanzadeh, Reza; Galbusera, Riccardo; Heijnen, Ingmar; Lalive, Patrice H; Wuerfel, Jens; Subramaniam, Suvitha; Aeschbacher, Stefanie; Conen, David; Naegelin, Yvonne; Maceski, Aleksandra; Meier, Stephanie; Berger, Klaus; Wiendl, Heinz; Lincke, Therese; Lieb, Johanna; Yaldizli, Özgür; Sinnecker, Tim; Derfuss, Tobias; Regeniter, Axel; Zecca, Chiara; Gobbi, Claudio; Kappos, Ludwig; Granziera, Cristina; Leppert, David; Kuhle, Jens.
Afiliação
  • Oechtering J; Neurology Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland.
  • Schaedelin S; Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Benkert P; Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Müller S; Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
  • Achtnichts L; Department of Neurology, Cantonal Hospital Aarau, Aarau, Switzerland.
  • Vehoff J; Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
  • Disanto G; Neurocentre of Southern Switzerland, Multiple Sclerosis Centre, Ospedale Civico, Lugano, Switzerland.
  • Findling O; Department of Neurology, Cantonal Hospital Aarau, Aarau, Switzerland.
  • Fischer-Barnicol B; Neurology Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland.
  • Orleth A; Neurology Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland.
  • Chan A; Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
  • Pot C; Division of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.
  • Barakovic M; Neurology Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland.
  • Rahmanzadeh R; Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
  • Galbusera R; Neurology Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland.
  • Heijnen I; Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
  • Lalive PH; Neurology Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland.
  • Wuerfel J; Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
  • Subramaniam S; Division of Medical Immunology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
  • Aeschbacher S; Department of Clinical Neurosciences, Division of Neurology, Geneva University Hospital, Geneva, Switzerland.
  • Conen D; Diagnostic Department, Division of Laboratory Medicine, Geneva University Hospital, Geneva, Switzerland.
  • Naegelin Y; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Maceski A; Medical Image Analysis Center (MIAC) and Department of Biomedical Engineering, University Basel, Basel, Switzerland.
  • Meier S; Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Berger K; Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
  • Wiendl H; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
  • Lincke T; Neurology Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland.
  • Lieb J; Neurology Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland.
  • Yaldizli Ö; Neurology Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland.
  • Sinnecker T; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
  • Derfuss T; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.
  • Regeniter A; Division of Neuroradiology, Department of Radiology and Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Zecca C; Division of Neuroradiology, Department of Radiology and Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Gobbi C; Neurology Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland.
  • Kappos L; Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
  • Granziera C; Neurology Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland.
  • Leppert D; Medical Image Analysis Center (MIAC) and Department of Biomedical Engineering, University Basel, Basel, Switzerland.
  • Kuhle J; Neurology Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, Basel, Switzerland.
Ann Neurol ; 90(3): 477-489, 2021 09.
Article em En | MEDLINE | ID: mdl-34057235
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Índice de Gravidade de Doença / Imunoglobulina M / Progressão da Doença / Esclerose Múltipla Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Índice de Gravidade de Doença / Imunoglobulina M / Progressão da Doença / Esclerose Múltipla Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article