COVID-19 spreading across world correlates with C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene prevalence.
J Clin Lab Anal
; 35(7): e23798, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-34061414
ABSTRACT
BACKGROUND:
Homocysteine assessment has been proposed as a potential predictive biomarker for the severity of COVID-19 infection. The purpose of this review was to analyze the correlation between the prevalence of MTHFR C677 T gene polymorphism and COVID-19 incidence and mortality worldwide.METHODS:
Data regarding MTHFR C677 T gene mutation were obtained from the interrogation of the Genome Aggregation Database (genomAD), which is publicly available from the web"https//gnomad.broadinstitute.org." COVID-19 cases, including prevalence and mortality, were obtained from"https//www.worldometers.info/coronavirus" 27 August 2020.RESULTS:
There is a clear trend toward the worldwide prevalence of MTHFR 677 T and COVID-19 incidence and mortality. The prevalence of MTHFR 677 T allele in the Latino population, and the incidence and mortality for COVID-19 was higher for this ethnic group than that reported for most other populations globally. Statistical analysis showed a relatively strong correlation between C677 T and death from coronavirus.CONCLUSIONS:
Genetic polymorphism of MTHFR C677 T may modulate the incidence and severity of COVID-19 pandemic infection.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metilenotetra-Hidrofolato Redutase (NADPH2)
/
Alelos
/
COVID-19
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article