Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant <sup>18</sup>F-Labelled &#963;<sub>2</sub> Receptor Ligand.

Moldovan, Rares-Petru; Gündel, Daniel; Teodoro, Rodrigo; Ludwig, Friedrich-Alexander; Fischer, Steffen; Toussaint, Magali; Schepmann, Dirk; Wünsch, Bernhard; Brust, Peter; Deuther-Conrad, Winnie

Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant ¹⁸F-Labelled σ₂ Receptor Ligand.

Moldovan, Rares-Petru; Gündel, Daniel; Teodoro, Rodrigo; Ludwig, Friedrich-Alexander; Fischer, Steffen; Toussaint, Magali; Schepmann, Dirk; Wünsch, Bernhard; Brust, Peter; Deuther-Conrad, Winnie.

Afiliação

Moldovan RP; Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.
Gündel D; Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.
Teodoro R; Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.
Ludwig FA; Life Molecular Imaging GmbH, Tegeler Str. 6-7, 13353 Berlin, Germany.
Fischer S; Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.
Toussaint M; Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.
Schepmann D; Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.
Wünsch B; Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster (WWU), Corrensstraße 48, 48149 Münster, Germany.
Brust P; Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster (WWU), Corrensstraße 48, 48149 Münster, Germany.
Deuther-Conrad W; Department of Neuroradiopharmaceuticals, Research Site Leipzig, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Permoserstraße 15, 04318 Leipzig, Germany.

Int J Mol Sci ; 22(11)2021 May 21.

Article em En | MEDLINE | ID: mdl-34064122

Assuntos

Encéfalo/metabolismo; Radioisótopos de Flúor/química; Radioisótopos de Flúor/metabolismo; Compostos Radiofarmacêuticos/química; Compostos Radiofarmacêuticos/metabolismo; Receptores sigma/metabolismo; Animais; Feminino; Humanos; Ligantes; Masculino; Camundongos; Neoplasias/metabolismo; Ratos; Ratos Endogâmicos F344; Tetra-Hidroisoquinolinas/química; Tetra-Hidroisoquinolinas/metabolismo

Palavras-chave

F98; azaindoles; binding affinity; brain-penetration; fluorine-18 labeling; glioblastoma; glioma; orthotopic; positron emission tomography (PET); radiochemistry; rat model; transmembrane protein 97; σ2 receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Radioisótopos de Flúor / Receptores sigma / Compostos Radiofarmacêuticos Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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