Effects of Thrombomodulin in Reducing Lethality and Suppressing Neutrophil Extracellular Trap Formation in the Lungs and Liver in a Lipopolysaccharide-Induced Murine Septic Shock Model.

Kato, Yu; Nishida, Osamu; Kuriyama, Naohide; Nakamura, Tomoyuki; Kawaji, Takahiro; Onouchi, Takanori; Hasegawa, Daisuke; Shimomura, Yasuyo

Kato, Yu; Nishida, Osamu; Kuriyama, Naohide; Nakamura, Tomoyuki; Kawaji, Takahiro; Onouchi, Takanori; Hasegawa, Daisuke; Shimomura, Yasuyo.

Afiliação

Kato Y; Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.
Nishida O; Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.
Kuriyama N; Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.
Nakamura T; Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.
Kawaji T; Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.
Onouchi T; Center for Joint Research Facilities Support, Research Promotion and Support Headquarters, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.
Hasegawa D; Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.
Shimomura Y; Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Japan.

Int J Mol Sci ; 22(9)2021 May 06.

Article em En | MEDLINE | ID: mdl-34066510

Assuntos

Armadilhas Extracelulares/metabolismo; Fígado/patologia; Pulmão/patologia; Choque Séptico/tratamento farmacológico; Trombomodulina/uso terapêutico; Animais; Citocinas/sangue; Modelos Animais de Doenças; Armadilhas Extracelulares/efeitos dos fármacos; Feminino; Humanos; Lipopolissacarídeos; Fígado/ultraestrutura; Camundongos Endogâmicos C57BL; Proteínas Recombinantes/administração & dosagem; Proteínas Recombinantes/farmacologia; Proteínas Recombinantes/uso terapêutico; Choque Séptico/sangue; Choque Séptico/induzido quimicamente; Análise de Sobrevida

Palavras-chave

lipopolysaccharide (LPS); neutrophil extracellular traps (NETs); organ dysfunction; sepsis; thrombomodulin

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Choque Séptico / Trombomodulina / Armadilhas Extracelulares / Fígado / Pulmão Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google