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A Comprehensive Review on the Role of Non-Coding RNAs in the Pathophysiology of Bipolar Disorder.
Ghafouri-Fard, Soudeh; Badrlou, Elham; Taheri, Mohammad; Dürsteler, Kenneth M; Beatrix Brühl, Annette; Sadeghi-Bahmani, Dena; Brand, Serge.
Afiliação
  • Ghafouri-Fard S; Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 65167198721, Iran.
  • Badrlou E; Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 65167198721, Iran.
  • Taheri M; Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran 65167198721, Iran.
  • Dürsteler KM; Psychiatric Clinics, Division of Substance Use Disorders, University of Basel, 4002 Basel, Switzerland.
  • Beatrix Brühl A; Center for Addictive Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8001 Zurich, Switzerland.
  • Sadeghi-Bahmani D; Center for Affective, Stress and Sleep Disorders (ZASS), Psychiatric University Hospital Basel, 4002 Basel, Switzerland.
  • Brand S; Center for Affective, Stress and Sleep Disorders (ZASS), Psychiatric University Hospital Basel, 4002 Basel, Switzerland.
Int J Mol Sci ; 22(10)2021 May 13.
Article em En | MEDLINE | ID: mdl-34068138
ABSTRACT

AIM:

Bipolar disorder is a multifactorial disorder being linked with dysregulation of several genes. Among the recently acknowledged factors in the pathophysiology of bipolar disorder are non-coding RNAs (ncRNAs).

METHODS:

We searched PubMed and Google Scholar databases to find studies that assessed the expression profile of miRNAs, lncRNAs and circRNAs in bipolar disorder.

RESULTS:

Dysregulated ncRNAs in bipolar patients have been enriched in several neuron-related pathways such as GABAergic and glutamatergic synapses, morphine addiction pathway and redox modulation.

CONCLUSION:

Altered expression of these transcripts in bipolar disorder provides clues for identification of the pathogenesis of this disorder and design of targeted therapies for the treatment of patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / RNA não Traduzido Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Bipolar / RNA não Traduzido Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article