Inactivation of the Akt/FOXM1 Signaling Pathway by Panobinostat Suppresses the Proliferation and Metastasis of Gastric Cancer Cells.

Lee, Na-Ri; Kim, Da-Yeah; Jin, Hua; Meng, Ruoyu; Chae, Ok Hee; Kim, Seong-Hun; Park, Byung-Hyun; Kim, Soo Mi

Lee, Na-Ri; Kim, Da-Yeah; Jin, Hua; Meng, Ruoyu; Chae, Ok Hee; Kim, Seong-Hun; Park, Byung-Hyun; Kim, Soo Mi.

Afiliação

Lee NR; Division of Hematology/Oncology, Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju 54907, Korea.
Kim DY; Research Institute of Clinical Medicine, Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea.
Jin H; Department of Physiology, Institute of Medical Science, Jeonbuk National University Medical School, Jeonju 54907, Korea.
Meng R; School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
Chae OH; Department of Physiology, Institute of Medical Science, Jeonbuk National University Medical School, Jeonju 54907, Korea.
Kim SH; Department of Anatomy, Institute of Medical Science, Jeonbuk National University Medical School, Jeonju 54907, Korea.
Park BH; Research Institute of Clinical Medicine, Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea.
Kim SM; Division of Gastroentrology, Department of Internal Medicine, Jeonbuk National University Medical School, Jeonbuk National University Hospital, Jeonju 54907, Korea.

Int J Mol Sci ; 22(11)2021 May 31.

Article em En | MEDLINE | ID: mdl-34073071

Assuntos

Antineoplásicos; Apoptose/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Panobinostat; Transdução de Sinais/efeitos dos fármacos; Neoplasias Gástricas/tratamento farmacológico; Animais; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Feminino; Proteína Forkhead Box M1/metabolismo; Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos; Humanos; Camundongos; Metástase Neoplásica/tratamento farmacológico; Panobinostat/farmacologia; Panobinostat/uso terapêutico; Proteínas Proto-Oncogênicas c-akt/metabolismo

Palavras-chave

FOXM1; apoptosis; cell cycle; gastric cancer cells; panobinostat

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Transdução de Sinais / Sobrevivência Celular / Apoptose / Panobinostat / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google