Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.

Mobbs, Jesse I; Belousoff, Matthew J; Harikumar, Kaleeckal G; Piper, Sarah J; Xu, Xiaomeng; Furness, Sebastian G B; Venugopal, Hari; Christopoulos, Arthur; Danev, Radostin; Wootten, Denise; Thal, David M; Miller, Laurence J; Sexton, Patrick M

Mobbs, Jesse I; Belousoff, Matthew J; Harikumar, Kaleeckal G; Piper, Sarah J; Xu, Xiaomeng; Furness, Sebastian G B; Venugopal, Hari; Christopoulos, Arthur; Danev, Radostin; Wootten, Denise; Thal, David M; Miller, Laurence J; Sexton, Patrick M.

Afiliação

Mobbs JI; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Belousoff MJ; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Harikumar KG; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Piper SJ; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, Arizona, United States of America.
Xu X; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Furness SGB; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Venugopal H; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Christopoulos A; Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, Victoria, Australia.
Danev R; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Wootten D; Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Thal DM; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Miller LJ; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Sexton PM; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

PLoS Biol ; 19(6): e3001295, 2021 06.

Article em En | MEDLINE | ID: mdl-34086670

Assuntos

Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP/metabolismo; Subunidades alfa Gs de Proteínas de Ligação ao GTP/metabolismo; Receptores da Colecistocinina/química; Receptores da Colecistocinina/metabolismo; Colecistocinina/metabolismo; Colesterol/metabolismo; Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP/química; Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP/ultraestrutura; Subunidades alfa Gs de Proteínas de Ligação ao GTP/química; Subunidades alfa Gs de Proteínas de Ligação ao GTP/ultraestrutura; Células HEK293; Humanos; Modelos Moleculares; Ligação Proteica; Receptores da Colecistocinina/ultraestrutura; Transdução de Sinais

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores da Colecistocinina / Subunidades alfa Gs de Proteínas de Ligação ao GTP / Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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