Extracellular HMGB1 augments macrophage inflammation by facilitating the endosomal accumulation of ALD-DNA via TLR2/4-mediated endocytosis.

Lu, Jincheng; Yue, Yan; Xiong, Sidong

Lu, Jincheng; Yue, Yan; Xiong, Sidong.

Afiliação

Lu J; Jiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Science, Soochow University, Suzhou 215123, People's Republic of China.
Yue Y; Jiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Science, Soochow University, Suzhou 215123, People's Republic of China. Electronic address: yysherry@163.com.
Xiong S; Jiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Science, Soochow University, Suzhou 215123, People's Republic of China. Electronic address: sdxiongfd@126.com.

Biochim Biophys Acta Mol Basis Dis ; 1867(10): 166184, 2021 10 01.

Article em En | MEDLINE | ID: mdl-34087422

Assuntos

DNA/metabolismo; Endocitose/fisiologia; Endossomos/metabolismo; Proteína HMGB1/metabolismo; Inflamação/imunologia; Macrófagos/metabolismo; Receptor 2 Toll-Like/metabolismo; Receptor 4 Toll-Like/metabolismo; Animais; Linhagem Celular; Feminino; Nefrite Lúpica/metabolismo; Ativação Linfocitária/fisiologia; Linfócitos/metabolismo; Camundongos; Camundongos Endogâmicos BALB C; Células RAW 264.7

Palavras-chave

ALD-DNA; Endocytosis; HMGB1; Macrophage inflammation; SLE

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endossomos / DNA / Proteína HMGB1 / Endocitose / Receptor 2 Toll-Like / Receptor 4 Toll-Like / Inflamação / Macrófagos Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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