Resurrection and characterization of ancestral CYP11A1 enzymes.

Hartz, Philip; Strohmaier, Silja J; El-Gayar, Basma M; Abdulmughni, Ammar; Hutter, Michael C; Hannemann, Frank; Gillam, Elizabeth M J; Bernhardt, Rita

Hartz, Philip; Strohmaier, Silja J; El-Gayar, Basma M; Abdulmughni, Ammar; Hutter, Michael C; Hannemann, Frank; Gillam, Elizabeth M J; Bernhardt, Rita.

Afiliação

Hartz P; Department of Biochemistry, Saarland University, Saarbrücken, Germany.
Strohmaier SJ; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Australia.
El-Gayar BM; Department of Biochemistry, Saarland University, Saarbrücken, Germany.
Abdulmughni A; Department of Biochemistry, Saarland University, Saarbrücken, Germany.
Hutter MC; Center for Bioinformatics, Saarland University, Saarbrücken, Germany.
Hannemann F; Department of Biochemistry, Saarland University, Saarbrücken, Germany.
Gillam EMJ; School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Australia.
Bernhardt R; Department of Biochemistry, Saarland University, Saarbrücken, Germany.

FEBS J ; 288(22): 6510-6527, 2021 11.

Article em En | MEDLINE | ID: mdl-34092040

Assuntos

Enzima de Clivagem da Cadeia Lateral do Colesterol; Enzima de Clivagem da Cadeia Lateral do Colesterol/genética; Enzima de Clivagem da Cadeia Lateral do Colesterol/isolamento & purificação; Enzima de Clivagem da Cadeia Lateral do Colesterol/metabolismo; Humanos; Filogenia

Palavras-chave

ancestral sequence reconstruction; cholesterol; cytochromes P450; pregnenolone formation; steroid hormone biosynthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Enzima de Clivagem da Cadeia Lateral do Colesterol Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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