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Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs.
Wang, Qingbo S; Kelley, David R; Ulirsch, Jacob; Kanai, Masahiro; Sadhuka, Shuvom; Cui, Ran; Albors, Carlos; Cheng, Nathan; Okada, Yukinori; Aguet, Francois; Ardlie, Kristin G; MacArthur, Daniel G; Finucane, Hilary K.
Afiliação
  • Wang QS; Broad Institute of MIT and Harvard, Cambridge, MA, USA. qingbow@broadinstitute.org.
  • Kelley DR; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. qingbow@broadinstitute.org.
  • Ulirsch J; PhD program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA. qingbow@broadinstitute.org.
  • Kanai M; Calico Life Sciences, South San Francisco, CA, USA.
  • Sadhuka S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Cui R; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
  • Albors C; PhD program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.
  • Cheng N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Okada Y; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
  • Aguet F; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Ardlie KG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • MacArthur DG; Harvard College, Cambridge, MA, USA.
  • Finucane HK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Nat Commun ; 12(1): 3394, 2021 06 07.
Article em En | MEDLINE | ID: mdl-34099641
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mapeamento Cromossômico / Biologia Computacional / Locos de Características Quantitativas / Aprendizado de Máquina Supervisionado Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mapeamento Cromossômico / Biologia Computacional / Locos de Características Quantitativas / Aprendizado de Máquina Supervisionado Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article