Chemodivergent manganese-catalyzed C-H activation: modular synthesis of fluorogenic probes.
Nat Commun
; 12(1): 3389, 2021 06 07.
Article
em En
| MEDLINE
| ID: mdl-34099672
ABSTRACT
Bioorthogonal late-stage diversification of amino acids and peptides bears enormous potential for drug discovery and molecular imaging. Despite major accomplishments, these strategies largely rely on traditional, lengthy prefunctionalization methods, heavily involving precious transition-metal catalysis. Herein, we report on a resource-economical manganese(I)-catalyzed C-H fluorescent labeling of structurally complex peptides ensured by direct alkynylation and alkenylation manifolds. This modular strategy sets the stage for unraveling structure-activity relationships between structurally discrete fluorophores towards the rational design of BODIPY fluorogenic probes for real-time analysis of immune cell function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Técnicas de Química Sintética
/
Corantes Fluorescentes
/
Manganês
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article