A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation.

Takahashi, Kanoko; Niki, Takahiro; Ogawa, Emari; Fumika, Kiku; Nishioka, Yu; Sawa, Masaaki; Arai, Hiroyuki; Mukai, Kojiro; Taguchi, Tomohiko

Takahashi, Kanoko; Niki, Takahiro; Ogawa, Emari; Fumika, Kiku; Nishioka, Yu; Sawa, Masaaki; Arai, Hiroyuki; Mukai, Kojiro; Taguchi, Tomohiko.

Afiliação

Takahashi K; Laboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan.
Niki T; Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
Ogawa E; RIKEN Center for Brain Science, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan.
Fumika K; Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
Nishioka Y; Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
Sawa M; Research and Development, Carna Biosciences, Inc., Kobe, Japan.
Arai H; Research and Development, Carna Biosciences, Inc., Kobe, Japan.
Mukai K; Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
Taguchi T; Laboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan. k_mukai@tohoku.ac.jp.

Sci Rep ; 11(1): 11996, 2021 06 07.

Article em En | MEDLINE | ID: mdl-34099821

Assuntos

Colesterol/metabolismo; Misturas Complexas/metabolismo; DNA/metabolismo; Fosforilação/efeitos dos fármacos; Esfingomielinas/metabolismo; Sistemas CRISPR-Cas; Citosol/metabolismo; Citosol/ultraestrutura; Retículo Endoplasmático/metabolismo; Técnicas de Silenciamento de Genes; Complexo de Golgi/metabolismo; Humanos; Fator Regulador 3 de Interferon/metabolismo; Interferon Tipo I/metabolismo; Lipoilação; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas Recombinantes/metabolismo; Transdução de Sinais; Esfingomielina Fosfodiesterase/metabolismo; beta-Ciclodextrinas/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosforilação / Esfingomielinas / DNA / Colesterol / Misturas Complexas Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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