Quantitation of Trace Levels of DNA Released from Disrupted Adeno-Associated Virus Gene Therapy Vectors.

Bee, Jared S; O'Berry, Kristin; Zhang, Yu Zoe; Phillippi, Megan Kuhn; Kaushal, Akanksha; DePaz, Roberto A; Marshall, Tristan

Bee, Jared S; O'Berry, Kristin; Zhang, Yu Zoe; Phillippi, Megan Kuhn; Kaushal, Akanksha; DePaz, Roberto A; Marshall, Tristan.

Afiliação

Bee JS; Formulation and Drug Product Development, REGENXBIO Inc., Rockville 20850, MD, USA. Electronic address: jbee@regenxbio.com.
O'Berry K; Formulation and Drug Product Development, REGENXBIO Inc., Rockville 20850, MD, USA.
Zhang YZ; Formulation and Drug Product Development, REGENXBIO Inc., Rockville 20850, MD, USA.
Phillippi MK; Formulation and Drug Product Development, REGENXBIO Inc., Rockville 20850, MD, USA.
Kaushal A; Analytical Sciences, REGENXBIO Inc., Rockville 20850, MD, USA.
DePaz RA; Formulation and Drug Product Development, REGENXBIO Inc., Rockville 20850, MD, USA.
Marshall T; Formulation and Drug Product Development, REGENXBIO Inc., Rockville 20850, MD, USA.

J Pharm Sci ; 110(9): 3183-3187, 2021 09.

Article em En | MEDLINE | ID: mdl-34107283

Assuntos

Dependovirus; Vetores Genéticos; DNA/genética; Dependovirus/genética; Congelamento; Terapia Genética

Palavras-chave

Adeno-Associated Virus (AAV); Degradation product; Deoxyribonucleic acid (DNA); Gene Vector; Gene therapy; Physical stability; Protein formulation; Stability

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dependovirus / Vetores Genéticos Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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