Recent Approaches to Targeting Canonical NFκB Signaling in the Early Inflammatory Response to Renal IRI.
J Am Soc Nephrol
; 32(9): 2117-2124, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-34108233
ABSTRACT
Ischemia reperfusion injury (IRI) is the most common cause of in-hospital AKI and is associated with increased morbidity and mortality. IRI is associated with an early phase of inflammation primarily regulated by the canonical NFκB signaling pathway. Despite recent advances in our understanding of the pathogenesis of IRI, few therapeutic strategies have emerged. The purpose of this manuscript is to review interventions targeting NFκB after IRI.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traumatismo por Reperfusão
/
NF-kappa B
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Injúria Renal Aguda
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article