A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance.

Warshauer, Jeremy T; Belk, Julia A; Chan, Alice Y; Wang, Jiaxi; Gupta, Alexander R; Shi, Quanming; Skartsis, Nikolaos; Peng, Yani; Phipps, Jonah D; Acenas, Dante; Smith, Jennifer A; Tamaki, Stanley J; Tang, Qizhi; Gardner, James M; Satpathy, Ansuman T; Anderson, Mark S

Warshauer, Jeremy T; Belk, Julia A; Chan, Alice Y; Wang, Jiaxi; Gupta, Alexander R; Shi, Quanming; Skartsis, Nikolaos; Peng, Yani; Phipps, Jonah D; Acenas, Dante; Smith, Jennifer A; Tamaki, Stanley J; Tang, Qizhi; Gardner, James M; Satpathy, Ansuman T; Anderson, Mark S.

Afiliação

Warshauer JT; Diabetes Center, University of California, San Francisco, San Francisco, CA.
Belk JA; Department of Medicine, University of California, San Francisco, San Francisco, CA.
Chan AY; Department of Computer Science, Stanford University, Stanford, CA.
Wang J; Department of Pediatrics, University of California, San Francisco, San Francisco, CA.
Gupta AR; Diabetes Center, University of California, San Francisco, San Francisco, CA.
Shi Q; Department of Surgery, University of California, San Francisco, San Francisco, CA.
Skartsis N; Department of Pathology, Stanford University, Stanford, CA.
Peng Y; Department of Medicine, University of California, San Francisco, San Francisco, CA.
Phipps JD; Department of Surgery, University of California, San Francisco, San Francisco, CA.
Acenas D; Diabetes Center, University of California, San Francisco, San Francisco, CA.
Smith JA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA.
Tamaki SJ; Diabetes Center, University of California, San Francisco, San Francisco, CA.
Tang Q; Department of Surgery, University of California, San Francisco, San Francisco, CA.
Gardner JM; Department of Surgery, University of California, San Francisco, San Francisco, CA.
Satpathy AT; Diabetes Center, University of California, San Francisco, San Francisco, CA.
Anderson MS; Department of Surgery, University of California, San Francisco, San Francisco, CA.

J Exp Med ; 218(8)2021 08 02.

Article em En | MEDLINE | ID: mdl-34115115

Assuntos

Linfócitos T CD8-Positivos/imunologia; Diabetes Mellitus Tipo 1/genética; Diabetes Mellitus Tipo 1/imunologia; Tolerância Imunológica/genética; Mutação/genética; Fator de Transcrição STAT3/genética; Animais; Autoimunidade; Proliferação de Células; Quimiotaxia/genética; Apresentação Cruzada/imunologia; Citotoxicidade Imunológica/genética; Modelos Animais de Doenças; Epigênese Genética; Mutação com Ganho de Função; Heterozigoto; Humanos; Camundongos; Fenótipo; Regulação para Cima

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Diabetes Mellitus Tipo 1 / Fator de Transcrição STAT3 / Tolerância Imunológica / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google