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The predictive value of clinical, radiographic, echocardiographic variables and cardiac biomarkers for assessing risk of the onset of heart failure or cardiac death in dogs with preclinical myxomatous mitral valve disease enrolled in the DELAY study.
Borgarelli, M; Ferasin, L; Lamb, K; Chiavegato, D; Bussadori, C; D'Agnolo, G; Migliorini, F; Poggi, M; Santilli, R A; Guillot, E; Garelli-Paar, C; Toschi Corneliani, R; Farina, F; Zani, A; Dirven, M; Smets, P; Guglielmini, C; Oliveira, P; Di Marcello, M; Porciello, F; Crosara, S; Ciaramella, P; Piantedosi, D; Smith, S; Vannini, S; Dall'Aglio, E; Savarino, P; Quintavalla, C; Patteson, M; Silva, J; Locatelli, C; Baron Toaldo, M.
Afiliação
  • Borgarelli M; Department Small Animal Clinical Science, Virginia Maryland College of Veterinary Medicine, Blacksburg, VA, USA. Electronic address: mborgarelli@gmail.com.
  • Ferasin L; Specialist Veterinary Cardiology Consultancy Ltd, Alton, Hampshire, UK.
  • Lamb K; Lamb Statiscal Consulting and Scientific Writing LLC, West St. Paul, MN, USA.
  • Chiavegato D; Clinica Veterinaria Arcella, Padova, Italy.
  • Bussadori C; Clinica Veterinaria Gran Sasso, Milan, Italy.
  • D'Agnolo G; Trieste, Italy.
  • Migliorini F; Ospedale Veterinario Croce Azzura, Roma, Italy.
  • Poggi M; Centro Veterinario Imperiese, Imperia, Italy.
  • Santilli RA; Clinica Veterinaria Malpensa, Samarate Varese, Italy.
  • Guillot E; Ceva Santé Animale, Libourne, France.
  • Garelli-Paar C; Ceva Santé Animale, Libourne, France.
  • Toschi Corneliani R; Ospedale Veterinario San Francesco, Milan, Italy.
  • Farina F; Ambulatorio Veterinario del Parco Margherita, Naples, Italy.
  • Zani A; Clinica Cardiovet, Livorno, Italy.
  • Dirven M; Dierenkliniek Rijen, Rijen, the Netherlands.
  • Smets P; Dierenkliniek Rijen, Rijen, the Netherlands.
  • Guglielmini C; Dipartimento di Medicina Animale, Produzione e Salute, Università di Padova, Legnaro, Padova, Italy.
  • Oliveira P; Davies Veterinary Specialists Ltd, Higham Gobion, Hertfordshire, UK.
  • Di Marcello M; Centro Veterinario Cellatica, Cellatica, Brescia, Italy.
  • Porciello F; Dipartimento di Medicina Veterinaria, Università degli Studi di Perugia, Perugia, Italy.
  • Crosara S; Clinica Veterinaria CMV, Varese, Italy.
  • Ciaramella P; Dipartimento di Medicina Veterinaria e Produzioni Animali, Università degli Studi di Napoli Federico II, Naples, Italy.
  • Piantedosi D; Dipartimento di Medicina Veterinaria e Produzioni Animali, Università degli Studi di Napoli Federico II, Naples, Italy.
  • Smith S; Sarah Smith Cardiology Ivy Court, Willington, UK.
  • Vannini S; Clinica Veterinaria Gran Sasso, Milan, Italy.
  • Dall'Aglio E; Clinica Veterinaria Milano Sud, Peschiera Borromeo, Milano, Italy.
  • Savarino P; Facoltà di Medicina Veterinaria di Torino, Ospedale Didattico Veterinario della Facoltà, Sezione Clinica Medica, Grugliasco, Turin, Italy.
  • Quintavalla C; Dipartimento di Scienze Mediche Veterinarie, Università di Parma, Parma, Italy.
  • Patteson M; Heartvets, The Animal Hospital Stinchcombe, Dursley, UK.
  • Silva J; Clinica Veterinaria Gran Sasso, Milan, Italy.
  • Locatelli C; Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milan, Italy.
  • Baron Toaldo M; Dipartimento di Scienze Mediche Veterinarie, Alma Mayor Studiorum, Università di Bologna, Ozzano Emilia, Italy.
J Vet Cardiol ; 36: 77-88, 2021 Aug.
Article em En | MEDLINE | ID: mdl-34118562
OBJECTIVES: To identify the predictive value on time to onset of heart failure (HF) or cardiac death of clinical, radiographic, and echocardiographic variables, as well as cardiac biomarkers N-terminal pro brain natriuretic peptide (NT-proBNP) and cardiac troponin I in dogs with preclinical myxomatous mitral valve disease (MMVD). ANIMALS: One hundred sixty-eight dogs with preclinical MMVD and left atrium to aortic root ratio ≥1.6 (LA:Ao) and normalized left ventricular end-diastolic diameter ≥1.7 were included. METHODS: Prospective, randomized, multicenter, single-blinded, placebo-controlled study. Clinical, radiographic, echocardiographic variables and plasma cardiac biomarkers concentrations were compared at different time points. Using receiving operating curves analysis, best cutoff for selected variables was identified and the risk to develop the study endpoint at six-month intervals was calculated. RESULTS: Left atrial to aortic root ratio >2.1 (hazard ratio [HR] 3.2, 95% confidence interval [95% CI] 1.9-5.6), normalized left ventricular end-diastolic diameter > 1.9 (HR: 6.3; 95% CI: 3.3-11.8), early transmitral peak velocity (E peak) > 1 m/sec (HR: 3.9; 95% CI: 2.3-6.7), and NT-proBNP > 1500 ρmol/L (HR: 5.7; 95% CI: 3.3-9.5) were associated with increased risk of HF or cardiac death. The best fit model to predict the risk to reach the endpoint was represented by the plasma NT-proBNP concentrations adjusted for LA:Ao and E peak. CONCLUSIONS: Logistic and survival models including echocardiographic variables and NT-proBNP can be used to identify dogs with preclinical MMVD at higher risk to develop HF or cardiac death.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Cão / Insuficiência Cardíaca Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças do Cão / Insuficiência Cardíaca Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article