Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy.

Mercer, Thomas John; Ohashi, Yohei; Boeing, Stefan; Jefferies, Harold B J; De Tito, Stefano; Flynn, Helen; Tremel, Shirley; Zhang, Wenxin; Wirth, Martina; Frith, David; Snijders, Ambrosius P; Williams, Roger Lee; Tooze, Sharon A

Mercer, Thomas John; Ohashi, Yohei; Boeing, Stefan; Jefferies, Harold B J; De Tito, Stefano; Flynn, Helen; Tremel, Shirley; Zhang, Wenxin; Wirth, Martina; Frith, David; Snijders, Ambrosius P; Williams, Roger Lee; Tooze, Sharon A.

Afiliação

Mercer TJ; Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, UK.
Ohashi Y; MRC Laboratory of Molecular Biology, Cambridge, UK.
Boeing S; Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK.
Jefferies HBJ; Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, UK.
De Tito S; Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, UK.
Flynn H; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council, Naples, Italy.
Tremel S; Institute of Experimental Endocrinology and Oncology (IEOS), National Research Council, Naples, Italy.
Zhang W; MRC Laboratory of Molecular Biology, Cambridge, UK.
Wirth M; Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, UK.
Frith D; Molecular Cell Biology of Autophagy, The Francis Crick Institute, London, UK.
Snijders AP; Proteomics, The Francis Crick Institute, London, UK.
Williams RL; Proteomics, The Francis Crick Institute, London, UK.
Tooze SA; MRC Laboratory of Molecular Biology, Cambridge, UK.

EMBO J ; 40(14): e105985, 2021 07 15.

Article em En | MEDLINE | ID: mdl-34121209

Assuntos

Proteína Homóloga à Proteína-1 Relacionada à Autofagia/metabolismo; Autofagia/fisiologia; Classe III de Fosfatidilinositol 3-Quinases/metabolismo; Proteína VPS15 de Distribuição Vacuolar/metabolismo; Proteínas Quinases Ativadas por AMP/metabolismo; Animais; Autofagossomos/metabolismo; Proteínas Relacionadas à Autofagia/metabolismo; Fibroblastos/metabolismo; Células HEK293; Humanos; Camundongos; Proteômica/métodos

Palavras-chave

PIK3R4; PRKAG2; ULK1; VPS15; p62

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Classe III de Fosfatidilinositol 3-Quinases / Proteína VPS15 de Distribuição Vacuolar / Proteína Homóloga à Proteína-1 Relacionada à Autofagia Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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