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Brain networks in patients with isolated or recurrent transient global amnesia.
Kim, Jinseung; Lee, Dong Ah; Kim, Hyung Chan; Lee, Ho-Joon; Park, Kang Min.
Afiliação
  • Kim J; Department of Family medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
  • Lee DA; Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
  • Kim HC; Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
  • Lee HJ; Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
  • Park KM; Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Acta Neurol Scand ; 144(5): 465-472, 2021 Nov.
Article em En | MEDLINE | ID: mdl-34128536
OBJECTIVES: The aim of this study was to investigate differences in cerebral blood flow (CBF) and functional networks between transient global amnesia (TGA) patients with a single event and those with recurrent events using arterial spin labeling (ASL) MRI. METHODS: We enrolled patients with TGA and classified them into two groups according to the number of TGA events: TGA patients with a single event and those with recurrent events. MRI scans were performed within 24 h after TGA ictal onset in all patients. We quantified CBF and analyzed the functional network based on CBF using graph theory, and determined the differences in CBF and functional networks between the groups. RESULTS: We enrolled 44 patients with TGA. Among them, 6 patients had recurrent TGA events, whereas 38 patients had a single TGA event. No regions had significantly different CBFs between TGA patients with recurrent events and those with a single event. The global functional network analysis found that the eccentricity was significantly higher in TGA patients with recurrent events than in those with a single event (5.829 vs. 4.657, p = .001). The local functional network analysis showed that several regions had significantly different betweenness centrality and eccentricity measures between TGA patients with recurrent events and those with a single event. CONCLUSIONS: We demonstrated the differences in the functional network based on CBF using graph theory according to recurrence in patients with TGA. These findings suggest that TGA is a network disease, and functional network alterations in TGA are related to clinical symptoms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amnésia Global Transitória Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amnésia Global Transitória Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article