A novel leukemic route of mutant NPM1 through nuclear import of the overexpressed long noncoding RNA LONA.

Gourvest, Morgane; De Clara, Etienne; Wu, Hsin-Chieh; Touriol, Christian; Meggetto, Fabienne; De Thé, Hugues; Pyronnet, Stéphane; Brousset, Pierre; Bousquet, Marina

Gourvest, Morgane; De Clara, Etienne; Wu, Hsin-Chieh; Touriol, Christian; Meggetto, Fabienne; De Thé, Hugues; Pyronnet, Stéphane; Brousset, Pierre; Bousquet, Marina.

Afiliação

Gourvest M; Cancer Research Center of Toulouse (CRCT), UMR1037 Inserm/Université Toulouse III Paul Sabatier, ERL5294 CNRS, Laboratoire d'excellence Toulouse Cancer (TOUCAN), Toulouse, France.
De Clara E; Cancer Research Center of Toulouse (CRCT), UMR1037 Inserm/Université Toulouse III Paul Sabatier, ERL5294 CNRS, Laboratoire d'excellence Toulouse Cancer (TOUCAN), Toulouse, France.
Wu HC; INSERM U944 and 1050, IRSL, University of Paris and PSL, Hôpital St. Louis and Collège de France, Paris, France.
Touriol C; Cancer Research Center of Toulouse (CRCT), UMR1037 Inserm/Université Toulouse III Paul Sabatier, ERL5294 CNRS, Laboratoire d'excellence Toulouse Cancer (TOUCAN), Toulouse, France.
Meggetto F; Cancer Research Center of Toulouse (CRCT), UMR1037 Inserm/Université Toulouse III Paul Sabatier, ERL5294 CNRS, Laboratoire d'excellence Toulouse Cancer (TOUCAN), Toulouse, France.
De Thé H; INSERM U944 and 1050, IRSL, University of Paris and PSL, Hôpital St. Louis and Collège de France, Paris, France.
Pyronnet S; Cancer Research Center of Toulouse (CRCT), UMR1037 Inserm/Université Toulouse III Paul Sabatier, ERL5294 CNRS, Laboratoire d'excellence Toulouse Cancer (TOUCAN), Toulouse, France.
Brousset P; Cancer Research Center of Toulouse (CRCT), UMR1037 Inserm/Université Toulouse III Paul Sabatier, ERL5294 CNRS, Laboratoire d'excellence Toulouse Cancer (TOUCAN), Toulouse, France.
Bousquet M; Cancer Research Center of Toulouse (CRCT), UMR1037 Inserm/Université Toulouse III Paul Sabatier, ERL5294 CNRS, Laboratoire d'excellence Toulouse Cancer (TOUCAN), Toulouse, France. bousquetmarina@gmail.com.

Leukemia ; 35(10): 2784-2798, 2021 10.

Article em En | MEDLINE | ID: mdl-34131282

Assuntos

Transporte Ativo do Núcleo Celular/genética; Núcleo Celular/genética; Leucemia Mieloide Aguda/genética; Mutação/genética; Proteínas Nucleares/genética; RNA Longo não Codificante/genética; Animais; Carcinogênese/genética; Diferenciação Celular/genética; Linhagem Celular Tumoral; Citoplasma/genética; Regulação Leucêmica da Expressão Gênica/genética; Células HL-60; Humanos; Masculino; Camundongos; Camundongos Endogâmicos NOD; Camundongos SCID; Nucleofosmina; RNA Mensageiro/genética; Microambiente Tumoral/genética

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Leucemia Mieloide Aguda / Núcleo Celular / Transporte Ativo do Núcleo Celular / RNA Longo não Codificante / Mutação Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google