Modifying splice site usage with ModCon: Maintaining the genetic code while changing the underlying mRNP code.

Ptok, Johannes; Müller, Lisa; Ostermann, Philipp Niklas; Ritchie, Anastasia; Dilthey, Alexander T; Theiss, Stephan; Schaal, Heiner

Modifying splice site usage with ModCon: Maintaining the genetic code while changing the underlying mRNP code.

Ptok, Johannes; Müller, Lisa; Ostermann, Philipp Niklas; Ritchie, Anastasia; Dilthey, Alexander T; Theiss, Stephan; Schaal, Heiner.

Afiliação

Ptok J; Institute of Virology, Medical Faculty, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Müller L; Institute of Virology, Medical Faculty, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Ostermann PN; Institute of Virology, Medical Faculty, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Ritchie A; Institute of Virology, Medical Faculty, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany.
Dilthey AT; Institute of Medical Statistics and Computational Biology, University of Cologne, Cologne, Germany.
Theiss S; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Schaal H; Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Comput Struct Biotechnol J ; 19: 3069-3076, 2021.

Article em En | MEDLINE | ID: mdl-34136105

Palavras-chave

A, adenine; F1, filial sequence 1; G, guanine; GA, genetic algorithm; HBS, HBond score; HBond score; HEXplorer score; HZEI, HEXplorer score; P1, parental sequence 1; SA, splice acceptor; SD, splice donor; SR proteins, serine- and arginine-rich proteins; SRP, splicing regulatory protein; SSHW, splice site HEXplorer weight; SW, sliding window; Splice donor; Splicing regulatory proteins; Splicing reporter; T, thymine; eGFP, enhanced green fluorescent protein; hnRNP, heterogeneous nuclear ribonucleoproteins; nt, nucleotides; pre-mRNA splicing; pre-mRNA, precursor messenger RNA; snRNA, small nuclear RNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article