Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations.

Saleh, Mohammed A A; Loo, Chi Fong; Elassaiss-Schaap, Jeroen; De Lange, Elizabeth C M

Saleh, Mohammed A A; Loo, Chi Fong; Elassaiss-Schaap, Jeroen; De Lange, Elizabeth C M.

Afiliação

Saleh MAA; Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Loo CF; Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Elassaiss-Schaap J; Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
De Lange ECM; PD-Value B.V, Houten, The Netherlands.

J Pharmacokinet Pharmacodyn ; 48(5): 725-741, 2021 Oct.

Article em En | MEDLINE | ID: mdl-34142308

Assuntos

Barreira Hematoencefálica/metabolismo; Encéfalo/metabolismo; Líquido Cefalorraquidiano/metabolismo; Líquido Extracelular/metabolismo; Animais; Transporte Biológico/fisiologia; Humanos; Modelos Biológicos; Ratos

Palavras-chave

Brain; CNS; Drug development; Physiologically-based pharmacokinetic models

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Barreira Hematoencefálica / Líquido Cefalorraquidiano / Líquido Extracelular Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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