Extracellular vesicles from thalassemia patients carry iron-containing ferritin and hemichrome that promote cardiac cell proliferation.

Atipimonpat, Anyapat; Siwaponanan, Panjaree; Khuhapinant, Archrob; Svasti, Saovaros; Sukapirom, Kasama; Khowawisetsut, Ladawan; Pattanapanyasat, Kovit

Atipimonpat, Anyapat; Siwaponanan, Panjaree; Khuhapinant, Archrob; Svasti, Saovaros; Sukapirom, Kasama; Khowawisetsut, Ladawan; Pattanapanyasat, Kovit.

Afiliação

Atipimonpat A; Graduate Program in Immunology, Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Siwaponanan P; Center of Excellence for Microparticle and Exosome in Diseases, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Khuhapinant A; Department of Biochemistry, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
Svasti S; Center of Excellence for Microparticle and Exosome in Diseases, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Sukapirom K; Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Khowawisetsut L; Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.
Pattanapanyasat K; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.

Ann Hematol ; 100(8): 1929-1946, 2021 Aug.

Article em En | MEDLINE | ID: mdl-34155536

Assuntos

Vesículas Extracelulares/patologia; Ferritinas/análise; Hemeproteínas/análise; Ferro/análise; Mioblastos Cardíacos/citologia; Talassemia/patologia; Adulto; Linhagem Celular; Proliferação de Células; Vesículas Extracelulares/metabolismo; Feminino; Ferritinas/metabolismo; Hemeproteínas/metabolismo; Células Endoteliais da Veia Umbilical Humana; Humanos; Ferro/metabolismo; Masculino; Pessoa de Meia-Idade; Mioblastos Cardíacos/metabolismo; Talassemia/sangue; Talassemia/metabolismo; Adulto Jovem

Palavras-chave

Cardiomyopathy; Exosomes; Extracellular vesicles; Ferritin; Hemichrome; Iron overload; Thalassemia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Talassemia / Mioblastos Cardíacos / Ferritinas / Vesículas Extracelulares / Hemeproteínas / Ferro Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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