Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F420H2-dependent reduction.

Aragaw, Wassihun Wedajo; Lee, Brendon M; Yang, Xuan; Zimmerman, Matthew D; Gengenbacher, Martin; Dartois, Véronique; Chui, Wai-Keung; Jackson, Colin J; Dick, Thomas

Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F₄₂₀H₂-dependent reduction.

Aragaw, Wassihun Wedajo; Lee, Brendon M; Yang, Xuan; Zimmerman, Matthew D; Gengenbacher, Martin; Dartois, Véronique; Chui, Wai-Keung; Jackson, Colin J; Dick, Thomas.

Afiliação

Aragaw WW; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.
Lee BM; Research School of Chemistry, The Australian National University, Acton 2601, Australia.
Yang X; Department of Pharmacy, Faculty of Science, National University of Singapore, 117543 Singapore, Singapore.
Zimmerman MD; Discovery Sciences R&D, Forward Pharmaceuticals Co., Ltd., 518057 Shenzhen, People's Republic of China.
Gengenbacher M; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.
Dartois V; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.
Chui WK; Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, NJ 07110.
Jackson CJ; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ 07110.
Dick T; Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, NJ 07110.

Proc Natl Acad Sci U S A ; 118(25)2021 06 22.

Article em En | MEDLINE | ID: mdl-34161270

Assuntos

Antagonistas do Ácido Fólico/farmacologia; Complexos Multienzimáticos/metabolismo; Mycobacterium tuberculosis/enzimologia; Oxirredutases/metabolismo; Tetra-Hidrofolato Desidrogenase/metabolismo; Cumarínicos/química; Cumarínicos/farmacologia; Farmacorresistência Bacteriana/efeitos dos fármacos; Ácido Fólico/metabolismo; Antagonistas do Ácido Fólico/química; Genes Bacterianos; Mutação com Perda de Função/genética; Simulação de Acoplamento Molecular; Mycobacterium tuberculosis/efeitos dos fármacos; Mycobacterium tuberculosis/genética; Oxirredução; Tetra-Hidrofolato Desidrogenase/genética

Palavras-chave

DHFR; F420; Mycobacterium tuberculosis; antibacterial

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredutases / Tetra-Hidrofolato Desidrogenase / Antagonistas do Ácido Fólico / Complexos Multienzimáticos / Mycobacterium tuberculosis Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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