Application of triazoles in the structural modification of natural products.
J Enzyme Inhib Med Chem
; 36(1): 1115-1144, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34167422
ABSTRACT
Nature products have been extensively used in the discovery and development of new drugs, as the most important source of drugs. The triazole ring is one of main pharmacophore of the nitrogen-containing heterocycles. Thus, a new class of triazole-containing natural product conjugates has been synthesised. These compounds reportedly exert anticancer, anti-inflammatory, antimicrobial, antiparasitic, antiviral, antioxidant, anti-Alzheimer, and enzyme inhibitory effects. This review summarises the research progress of triazole-containing natural product derivatives involved in medicinal chemistry in the past six years. This review provides insights and perspectives that will help scientists in the fields of organic synthesis, medicinal chemistry, phytochemistry, and pharmacology.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triazóis
/
Produtos Biológicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article