Associations of Nutrient Intake Changes During Childhood with Adolescent Hepatic Fat: The Exploring Perinatal Outcomes Among CHildren Study.
J Pediatr
; 237: 50-58.e3, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34171361
ABSTRACT
OBJECTIVE:
To examine associations of dietary changes from childhood to adolescence with adolescent hepatic fat and whether the PNPLA3 rs738409 risk allele, a strong genetic risk factor for hepatic fat, modifies associations. STUDYDESIGN:
Data were from 358 participants in the Exploring Perinatal Outcomes among CHildren (EPOCH) study, a longitudinal cohort in Colorado. Diet was assessed by food frequency questionnaire in childhood (approximately 10 years of age) and adolescence (approximately 16 years of age) and converted to nutrient densities. Hepatic fat was assessed in adolescence by magnetic resonance imaging. Linear regression was used to test associations of dietary changes from childhood to adolescence with adolescent hepatic fat.RESULTS:
Increases in fiber, vegetable protein, and polyunsaturated fat intake from childhood to adolescence were associated with lower adolescent hepatic fat, and increases in animal protein were associated with higher hepatic fat (ß per 5-unit increase on log-hepatic fat -0.12 [95% CI, -0.21 to -0.02] for âµfiber; -0.26 [95% CI, -0.45 to -0.07] for âµvegetable protein; -0.18 [95% CI, -0.35 to -0.02] for âµpolyunsaturated fat; 0.13 [95% CI, 0.04-0.22] for âµanimal protein). There was evidence of effect modification by PNPLA3 variant, whereby inverse associations of âµfiber and âµvegetable protein and positive associations of âµsaturated fat with adolescent hepatic fat were stronger in risk allele carriers. Most conclusions were similar after adjusting for obesity in adolescence, but associations of âµsaturated fat with hepatic fat were attenuated toward the null.CONCLUSIONS:
Our results suggest that nutrient intake changes between childhood and adolescence, particularly decreases in fiber and vegetable protein and increases in saturated fat intake, interact with the PNPLA3 variant to predict higher hepatic fat in adolescence, and may be targets for reducing hepatic fat in high-risk youth.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dieta
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Fígado Gorduroso
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article