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Review of the Role of the Brain in Chemotherapy-Induced Peripheral Neuropathy.
Omran, Maryam; Belcher, Elizabeth K; Mohile, Nimish A; Kesler, Shelli R; Janelsins, Michelle C; Hohmann, Andrea G; Kleckner, Ian R.
Afiliação
  • Omran M; University of Rochester Medical Center, Rochester, NY, United States.
  • Belcher EK; University of Rochester Medical Center, Rochester, NY, United States.
  • Mohile NA; University of Rochester Medical Center, Rochester, NY, United States.
  • Kesler SR; The University of Texas at Austin, Austin, TX, United States.
  • Janelsins MC; University of Rochester Medical Center, Rochester, NY, United States.
  • Hohmann AG; Psychological and Brain Sciences, Program in Neuroscience and Gill Center for Biomolecular Science, Indiana University Bloomington, Bloomington, IN, United States.
  • Kleckner IR; University of Rochester Medical Center, Rochester, NY, United States.
Front Mol Biosci ; 8: 693133, 2021.
Article em En | MEDLINE | ID: mdl-34179101
Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating, and dose-limiting side effect of many chemotherapy regimens yet has limited treatments due to incomplete knowledge of its pathophysiology. Research on the pathophysiology of CIPN has focused on peripheral nerves because CIPN symptoms are felt in the hands and feet. However, better understanding the role of the brain in CIPN may accelerate understanding, diagnosing, and treating CIPN. The goals of this review are to (1) investigate the role of the brain in CIPN, and (2) use this knowledge to inform future research and treatment of CIPN. We identified 16 papers using brain interventions in animal models of CIPN and five papers using brain imaging in humans or monkeys with CIPN. These studies suggest that CIPN is partly caused by (1) brain hyperactivity, (2) reduced GABAergic inhibition, (3) neuroinflammation, and (4) overactivation of GPCR/MAPK pathways. These four features were observed in several brain regions including the thalamus, periaqueductal gray, anterior cingulate cortex, somatosensory cortex, and insula. We discuss how to leverage this knowledge for future preclinical research, clinical research, and brain-based treatments for CIPN.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article