Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting: A meta-analysis of randomized controlled trials.
Saudi Med J
; 42(7): 707-713, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-34187913
ABSTRACT
OBJECTIVES:
To compare the efficacy of prophylactic ondansetron and tropisetron for postoperative nausea and vomiting (PONV).METHODS:
A literature search was performed to identify studies that compare the efficiency of ondansetron with that of tropisetron in preventing PONV. Only randomized controlled trials updated to January, 2021 were included.RESULTS:
The final pooled analysis included 14 studies totaling 1705 patients and indicated that ondansetron was 39% less effective than tropisetron in preventing postoperative vomiting with a higher incidence of dizziness. However, no significant difference was detected between ondansetron and tropisetron in PONV, postoperative nausea, antiemetic treatment, and headache.CONCLUSIONS:
Tropisetron is superior to ondansetron in preventing postoperative vomiting.PROSPERO No CRD42021237368.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Náusea e Vômito Pós-Operatórios
/
Antieméticos
Tipo de estudo:
Clinical_trials
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article