Core Steps to the Azaphilone Family of Fungal Natural Products.
Chembiochem
; 22(21): 3027-3036, 2021 11 03.
Article
em En
| MEDLINE
| ID: mdl-34190382
ABSTRACT
Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed consensus scheme for the production of the core azaphilone structure, as well as identifying early diversification steps during azaphilone biosynthesis. A consensus understanding of the core enzymatic steps towards a particular family of fungal natural products can aid in genome-mining experiments. Genome mining for novel fungal natural products is a powerful technique for both exploring chemical space and providing new insights into fungal natural product pathways.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pigmentos Biológicos
/
Produtos Biológicos
/
Monascus
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article