An Investigation into the Potential of Targeting <i>Escherichia coli rne</i> mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy.

Goddard, Layla R; Mardle, Charlotte E; Gneid, Hassan; Ball, Ciara G; Gowers, Darren M; Atkins, Helen S; Butt, Louise E; Watts, Jonathan K; Vincent, Helen A; Callaghan, Anastasia J

An Investigation into the Potential of Targeting Escherichia coli rne mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy.

Goddard, Layla R; Mardle, Charlotte E; Gneid, Hassan; Ball, Ciara G; Gowers, Darren M; Atkins, Helen S; Butt, Louise E; Watts, Jonathan K; Vincent, Helen A; Callaghan, Anastasia J.

Afiliação

Goddard LR; School of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.
Mardle CE; Centre for Enzyme Innovation, University of Portsmouth, Portsmouth PO1 2DY, UK.
Gneid H; School of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.
Ball CG; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01609, USA.
Gowers DM; Department of Chemistry, University of Southampton, Southampton SO17 1BJ, UK.
Atkins HS; School of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.
Butt LE; Centre for Enzyme Innovation, University of Portsmouth, Portsmouth PO1 2DY, UK.
Watts JK; School of Biological Sciences and Institute of Biological & Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DY, UK.
Vincent HA; Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK.
Callaghan AJ; College of Life and Environmental Sciences, University of Exeter, Exeter EX4 4QD, UK.

Molecules ; 26(11)2021 Jun 04.

Article em En | MEDLINE | ID: mdl-34200016

Assuntos

Antibacterianos/farmacologia; Endorribonucleases/genética; Escherichia coli/enzimologia; Oligonucleotídeos/farmacologia; Sistema Livre de Células; Endorribonucleases/antagonistas & inibidores; Escherichia coli/efeitos dos fármacos; Proteínas de Escherichia coli/genética; Oligonucleotídeos/síntese química; Iniciação Traducional da Cadeia Peptídica/efeitos dos fármacos; RNA Mensageiro/antagonistas & inibidores

Palavras-chave

RNase E; RNase H; antibacterial; antisense oligonucleotide; gapmer; locked nucleic acid (LNA); rne mRNA; translation blocking

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / Endorribonucleases / Escherichia coli / Antibacterianos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google