Direct Amidation to Access 3-Amido-1,8-Naphthalimides Including Fluorescent Scriptaid Analogues as HDAC Inhibitors.

Hearn, Kyle N; Ashton, Trent D; Acharya, Rameshwor; Feng, Zikai; Gueven, Nuri; Pfeffer, Frederick M

Hearn, Kyle N; Ashton, Trent D; Acharya, Rameshwor; Feng, Zikai; Gueven, Nuri; Pfeffer, Frederick M.

Afiliação

Hearn KN; School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC 3216, Australia.
Ashton TD; STEM College, RMIT University, Melbourne, VIC 3000, Australia.
Acharya R; School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC 3216, Australia.
Feng Z; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Gueven N; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.
Pfeffer FM; School of Pharmacy and Pharmacology, College of Health and Medicine, University of Tasmania, Hobart, TAS 7001, Australia.

Cells ; 10(6)2021 06 15.

Article em En | MEDLINE | ID: mdl-34203745

Assuntos

Inibidores de Histona Desacetilases/química; Hidroxilaminas/química; Naftalenos/química; Quinolinas/química; Acetilação; Amidas/química; Inibidores de Histona Desacetilases/farmacologia; Histona Desacetilases/metabolismo; Ácidos Hidroxâmicos/farmacologia; Indóis/farmacologia; Naftalimidas/química

Palavras-chave

1,8-naphthalimide; BuchwaldHartwig; HDAC; fluorescence; histone deacetylase; imaging; scriptaid; tubulin deacetylase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Inibidores de Histona Desacetilases / Hidroxilaminas / Naftalenos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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