Your browser doesn't support javascript.
loading
Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes.
Watanabe, Shinichi; Iozumi, Ken; Abe, Masatoshi; Ito, Yoshiko; Uesugi, Takashi; Onoduka, Takashi; Kato, Ichiro; Kato, Fumihiro; Kodama, Kazuo; Takahashi, Hidetoshi; Takeda, Osamu; Tomizawa, Koki; Tateishi, Yasuki; Fujii, Mizue; Mayama, Jun; Muramoto, Fumio; Yasuda, Hidemi; Yamanaka, Kiyomitsu; Oh-I, Tsunao; Kasai, Hiroko; Tsuboi, Ryoji; Hattori, Naoko; Maruyama, Ryuji; Omi, Tokuya; Shimoyama, Harunari; Nakasu, Ichiro; Watanabe-Okada, Emiko; Nishimoto, Shuhei; Mochizuki, Takashi; Fukuzawa, Masao; Seishima, Mariko; Sugiura, Kazumitsu; Yamamoto, Osamu; Shindo, Masahisa; Kiryu, Hiroe; Kusuhara, Masahiro; Takenaka, Motoi.
Afiliação
  • Watanabe S; Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
  • Iozumi K; Department of Dermatology, Tokyo Metropolitan Police Hospital, Tokyo, Japan.
  • Abe M; Sapporo Skin Clinic, Sapporo, Japan.
  • Ito Y; Ito Skin Clinic, Sapporo, Japan.
  • Uesugi T; Uesugi Dermatology Clinic, Sapporo, Japan.
  • Onoduka T; Asanuma Dermatology Clinic, Chitose, Japan.
  • Kato I; Eniwa Station Dermatology Clinic, Eniwa, Japan.
  • Kato F; Kato Dermatology Clinic, Sapporo, Japan.
  • Kodama K; Megumino Dermatologic Clinic, Eniwa, Japan.
  • Takahashi H; Takagi Dermatological Clinic, Obihiro, Japan.
  • Takeda O; Takeda Dermatological Skin Care Clinic, Sapporo, Japan.
  • Tomizawa K; Nopporo Dermatology Clinic, Ebetsu, Japan.
  • Tateishi Y; Showa Skin Clinic, Hakodate, Japan.
  • Fujii M; Department of Dermatology, Asahikawa Medical University Hospital, Asahikawa, Japan.
  • Mayama J; Chitose Dermatology and Plastic Surgery Clinic, Chitose,, Japan.
  • Muramoto F; Shinoro Dermatology Clinic, Sapporo, Japan.
  • Yasuda H; Fukuzumi Dermatology Clinic, Sapporo, Japan.
  • Yamanaka K; Yamanaka Skincare Clinic, Sapporo, Japan.
  • Oh-I T; Atago Dermatology Clinic, Tokyo, Japan.
  • Kasai H; Department of Dermatology, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
  • Tsuboi R; Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
  • Hattori N; Naoko Dermatology Clinic, Tokyo, Japan.
  • Maruyama R; Maruyama Dermatology Clinic, Tokyo, Japan.
  • Omi T; Queen's Square Medical Center, Yokohama, Japan.
  • Shimoyama H; Department of Dermatology, Teikyo University Mizonokuchi Hospital, Kawasaki, Japan.
  • Nakasu I; Nemunoki Dermatology Clinic, Kawasaki, Japan.
  • Watanabe-Okada E; Department of Dermatology, Saiseikai Yokohama-shi Tobu Hospital, Yokohama, Japan.
  • Nishimoto S; Department of Dermatology, Saiseikai Kanagawa Hospital, Yokohama, Japan.
  • Mochizuki T; Department of Dermatology, Kawasaki Municipal Hospital, Kawasaki, Japan.
  • Fukuzawa M; Department of Dermatology, Kanazawa Medical University, Kanazawa, Japan.
  • Seishima M; Department of Dermatology, Ina Central Hospital, Ina, Japan.
  • Sugiura K; Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Yamamoto O; Department of Dermatology, Fujita Health University, Toyoake, Japan.
  • Shindo M; Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Tottori University Faculty of Medicine, Yonago, Japan.
  • Kiryu H; Department of Dermatology, National Hospital Organization Hamada Medical Center, Hamada, Japan.
  • Kusuhara M; Kiryu Dermatology Clinic, Fukuoka, Japan.
  • Takenaka M; Kusuhara Dermatology Clinic, Fukuoka, Japan.
J Dermatol ; 48(10): 1474-1481, 2021 Oct.
Article em En | MEDLINE | ID: mdl-34212423
ABSTRACT
Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory to oral drugs as with dermatophytoma. We evaluated the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes. Of the 223 subjects who were enrolled in a previous study, a post-hoc analysis of 82 subjects with longitudinal spikes was performed in this study. The opacity ratio of longitudinal spikes was decreased over time from 8.1 to 0.9 at the final assessment. In addition, the longitudinal spike disappearance rate increased early after the application to 81.7% at the final assessment. Therefore, 10% efinaconazole solution can be a first-line drug for longitudinal spikes, which have been regarded as refractory to oral drugs.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Onicomicose Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Onicomicose Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article