Carbonic-anhydrase IX expression is increased in thyroid cancer tissue and represents a potential therapeutic target to eradicate thyroid tumor-initiating cells.

Schmidt, Jennifer; Oppermann, Elsie; Blaheta, Roman A; Schreckenbach, Teresa; Lunger, Ilaria; Rieger, Michael A; Bechstein, Wolf Otto; Holzer, Katharina; Malkomes, Patrizia

Schmidt, Jennifer; Oppermann, Elsie; Blaheta, Roman A; Schreckenbach, Teresa; Lunger, Ilaria; Rieger, Michael A; Bechstein, Wolf Otto; Holzer, Katharina; Malkomes, Patrizia.

Afiliação

Schmidt J; Hospital of the Goethe University Frankfurt, Department of General, Visceral and Transplant Surgery, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Oppermann E; Hospital of the Goethe University Frankfurt, Department of General, Visceral and Transplant Surgery, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Blaheta RA; Hospital of the Goethe University Frankfurt, Department of Urology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Schreckenbach T; Hospital of the Goethe University Frankfurt, Department of General, Visceral and Transplant Surgery, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Lunger I; Hospital of the Goethe University Frankfurt, Department of General, Visceral and Transplant Surgery, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany; Hospital of the Goethe University Frankfurt, Department of Inner Medicine, Hematology/Oncology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main,
Rieger MA; Hospital of the Goethe University Frankfurt, Department of Inner Medicine, Hematology/Oncology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany; German Cancer Consortium and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany; Frankfurt Cancer Institute,
Bechstein WO; Hospital of the Goethe University Frankfurt, Department of General, Visceral and Transplant Surgery, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Holzer K; Hospital of the Goethe University Frankfurt, Department of General, Visceral and Transplant Surgery, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany; Philipps University Hospital of Marburg, Section of Endocrine Surgery, Department of Visceral-, Thoracic- and Vascular Surgery, Baldingerstraße
Malkomes P; Hospital of the Goethe University Frankfurt, Department of General, Visceral and Transplant Surgery, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. Electronic address: Patrizia.Malkomes@kgu.de.

Mol Cell Endocrinol ; 535: 111382, 2021 09 15.

Article em En | MEDLINE | ID: mdl-34216643

Assuntos

Antígenos de Neoplasias/genética; Antígenos de Neoplasias/metabolismo; Anidrase Carbônica IX/genética; Anidrase Carbônica IX/metabolismo; Células-Tronco Neoplásicas/metabolismo; Neoplasias da Glândula Tireoide/patologia; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Estudos de Casos e Controles; Pontos de Checagem do Ciclo Celular; Linhagem Celular Tumoral; Proliferação de Células; Regulação Neoplásica da Expressão Gênica; Humanos; Metástase Linfática; Estadiamento de Neoplasias; Células-Tronco Neoplásicas/patologia; Análise de Sobrevida; Neoplasias da Glândula Tireoide/genética; Neoplasias da Glândula Tireoide/metabolismo; Neoplasias da Glândula Tireoide/mortalidade; Regulação para Cima

Palavras-chave

Carbonic-anhydrase IX; Hypoxia; Methazolamide; Thyroid cancer; Tumor-initiating cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Neoplasias da Glândula Tireoide / Anidrase Carbônica IX / Antígenos de Neoplasias Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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