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Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction.
Gentzel, Renee C; Toolan, Dawn; Jinn, Sarah; Schachter, Joel B; Ma, Lei; Kahle, Philipp J; Smith, Sean M; Marcus, Jacob N.
Afiliação
  • Gentzel RC; Neuroscience Discovery, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Toolan D; Neuroscience Discovery, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Jinn S; Neuroscience Discovery, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Schachter JB; Neuroscience Discovery, Merck & Co., Inc., Kenilworth, NJ, USA; Currently at Takeda Pharmaceutics, Inc., San Diego, CA, USA.
  • Ma L; Neuroscience Discovery, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Kahle PJ; Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and, German Center for Neurodegenerative Diseases, University of Tübingen, Germany.
  • Smith SM; Neuroscience Discovery, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Marcus JN; Neuroscience Discovery, Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address: jacob_marcus@merck.com.
Neurobiol Aging ; 106: 12-25, 2021 10.
Article em En | MEDLINE | ID: mdl-34225000
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microglia / Alfa-Sinucleína / Sinucleinopatias Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microglia / Alfa-Sinucleína / Sinucleinopatias Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article