Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism.

Matsumoto, Shogo; Kamimura, Hidetaka; Nishiwaki, Megumi; Cho, Naoki; Kato, Kazuhiko; Yamamoto, Taichi

Matsumoto, Shogo; Kamimura, Hidetaka; Nishiwaki, Megumi; Cho, Naoki; Kato, Kazuhiko; Yamamoto, Taichi.

Afiliação

Matsumoto S; Meiji Seika Pharma Co., Ltd., Pharmaceutical Research Labs, Yokohama, Japan.
Kamimura H; Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan.
Nishiwaki M; CLEA Japan Inc, Meguro-ku, Japan.
Cho N; Meiji Seika Pharma Co., Ltd., Pharmaceutical Research Labs, Yokohama, Japan.
Kato K; Meiji Seika Pharma Co., Ltd., Pharmaceutical Research Labs, Yokohama, Japan.
Yamamoto T; In Vivo Science Inc, Kawasaki, Japan.

Xenobiotica ; 51(9): 983-994, 2021 Sep.

Article em En | MEDLINE | ID: mdl-34227923

Assuntos

Preparações Farmacêuticas; Animais; Quimera; Hepatócitos; Humanos; Fígado/metabolismo; Taxa de Depuração Metabólica; Camundongos; Preparações Farmacêuticas/metabolismo

Palavras-chave

Allometry; chimeric mouse; metabolic clearance; physiologically based scaling; prediction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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