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Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques.
Van Rompay, Koen K A; Olstad, Katherine J; Sammak, Rebecca L; Dutra, Joseph; Watanabe, Jennifer K; Usachenko, Jodie L; Immareddy, Ramya; Verma, Anil; Shaan Lakshmanappa, Yashavanth; Schmidt, Brian A; Roh, Jamin W; Elizaldi, Sonny R; Allen, A Mark; Muecksch, Frauke; Lorenzi, Julio C C; Lockwood, Sarah; Pollard, Rachel E; Yee, JoAnn L; Nham, Peter B; Ardeshir, Amir; Deere, Jesse D; Patterson, Jean; Dang, Que; Hatziioannou, Theodora; Bieniasz, Paul D; Iyer, Smita S; Hartigan-O'Connor, Dennis J; Nussenzweig, Michel C; Reader, J Rachel.
Afiliação
  • Van Rompay KKA; California National Primate Research Center, University of California, Davis, United States of America.
  • Olstad KJ; Department of Pathology, Microbiology and Immunology, University of California, Davis, California, United States of America.
  • Sammak RL; California National Primate Research Center, University of California, Davis, United States of America.
  • Dutra J; Department of Pathology, Microbiology and Immunology, University of California, Davis, California, United States of America.
  • Watanabe JK; California National Primate Research Center, University of California, Davis, United States of America.
  • Usachenko JL; Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California, United States of America.
  • Immareddy R; California National Primate Research Center, University of California, Davis, United States of America.
  • Verma A; California National Primate Research Center, University of California, Davis, United States of America.
  • Shaan Lakshmanappa Y; California National Primate Research Center, University of California, Davis, United States of America.
  • Schmidt BA; Center for Immunology and Infectious Diseases, University of California, Davis, California, United States of America.
  • Roh JW; Center for Immunology and Infectious Diseases, University of California, Davis, California, United States of America.
  • Elizaldi SR; Center for Immunology and Infectious Diseases, University of California, Davis, California, United States of America.
  • Allen AM; Center for Immunology and Infectious Diseases, University of California, Davis, California, United States of America.
  • Muecksch F; Center for Immunology and Infectious Diseases, University of California, Davis, California, United States of America.
  • Lorenzi JCC; California National Primate Research Center, University of California, Davis, United States of America.
  • Lockwood S; Laboratory of Retrovirology, The Rockefeller University, New York, New York, United States of America.
  • Pollard RE; Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America.
  • Yee JL; California National Primate Research Center, University of California, Davis, United States of America.
  • Nham PB; School of Veterinary Medicine, University of California, Davis, California, United States of America.
  • Ardeshir A; California National Primate Research Center, University of California, Davis, United States of America.
  • Deere JD; California National Primate Research Center, University of California, Davis, United States of America.
  • Patterson J; California National Primate Research Center, University of California, Davis, United States of America.
  • Dang Q; Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California, United States of America.
  • Hatziioannou T; Translational Research Section, Virology Branch, DMID/NIAID/NIH, Rockville, Maryland, United States of America.
  • Bieniasz PD; Preclinical Research and Development Branch, Vaccine Research Program, DAIDS/NIAID/NIH, Rockville, Maryland, United States of America.
  • Iyer SS; Laboratory of Retrovirology, The Rockefeller University, New York, New York, United States of America.
  • Hartigan-O'Connor DJ; Laboratory of Retrovirology, The Rockefeller University, New York, New York, United States of America.
  • Nussenzweig MC; Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America.
  • Reader JR; California National Primate Research Center, University of California, Davis, United States of America.
PLoS Pathog ; 17(7): e1009688, 2021 07.
Article em En | MEDLINE | ID: mdl-34228761
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Replicação Viral / Anticorpos Neutralizantes / SARS-CoV-2 / COVID-19 / Pulmão / Anticorpos Antivirais Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Replicação Viral / Anticorpos Neutralizantes / SARS-CoV-2 / COVID-19 / Pulmão / Anticorpos Antivirais Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article