Protective succinate-SUCNR1 metabolic stress signaling gone bad.
Cell Metab
; 33(7): 1276-1278, 2021 07 06.
Article
em En
| MEDLINE
| ID: mdl-34233171
ABSTRACT
The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Succínico
/
Receptores Acoplados a Proteínas G
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article