Protective succinate-SUCNR1 metabolic stress signaling gone bad.

Winther, Sally; Trauelsen, Mette; Schwartz, Thue W

Winther, Sally; Trauelsen, Mette; Schwartz, Thue W.

Afiliação

Winther S; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Panum Institute, Mærsk Tower 07.6, Blegdamsvej 3B, Copenhagen, Denmark.
Trauelsen M; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Panum Institute, Mærsk Tower 07.6, Blegdamsvej 3B, Copenhagen, Denmark.
Schwartz TW; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Panum Institute, Mærsk Tower 07.6, Blegdamsvej 3B, Copenhagen, Denmark. Electronic address: tws@sund.ku.dk.

Cell Metab ; 33(7): 1276-1278, 2021 07 06.

Article em En | MEDLINE | ID: mdl-34233171

ABSTRACT

ABSTRACT

The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.

Assuntos

Receptores Acoplados a Proteínas G; Ácido Succínico; Animais; Fibrose; Camundongos; Transdução de Sinais; Estresse Fisiológico

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Succínico / Receptores Acoplados a Proteínas G Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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