The next generation: Urinary epidermal growth factor is associated with an early decline in kidney function in children and adolescents with type 1 diabetes mellitus.
Diabetes Res Clin Pract
; 178: 108945, 2021 Aug.
Article
em En
| MEDLINE
| ID: mdl-34245799
ABSTRACT
AIMS:
Micro-albuminuria is considered an early clinical sign of diabetes nephropathy, however, early decrease of glomerular filtration can be present years before the presence of microalbuminuria. In this study, we explored whether urinary epidermal growth factor (uEGF) might serve as an early marker of diabetes nephropathy compared to microalbuminuria in children and adolescents.METHODS:
Children with type 1 diabetes mellitus (nâ¯=â¯158) and healthy controls (nâ¯=â¯40) were included in this study. Serum and urine samples were collected three times with an interval of at least one month to determine creatinine (serum and urine), epidermal growth factor and albumin (urine). Demographic data and routine lab values were extracted out of the electronic patient files.RESULTS:
uEGF was significantly lower in children with T1DM compared to healthy controls (pâ¯=â¯0.032). A relatively lower glomerular filtration rate (eGFR) was associated with a decreased uEGF (pâ¯<â¯0.001). uEGF was independently associated with eGFR in a multivariate analysis.CONCLUSION:
This study provides evidence that uEGF can serve as an early marker of diabetes nephropathy in children and adolescents.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 1
/
Nefropatias Diabéticas
/
Fator de Crescimento Epidérmico
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article