The Non-Steroidal Mineralocorticoid Receptor Antagonist KBP-5074 Limits Albuminuria and has Improved Therapeutic Index Compared With Eplerenone in a Rat Model With Mineralocorticoid-Induced Renal Injury.

Jaisser, Frédéric; Tan, Xiaojuan; Chi, Shuangshuang; Liu, Jinrong; Wang, Ping; Bush, Mark; Benn, Vincent; Yang, Y Fred; Zhang, Jay

Jaisser, Frédéric; Tan, Xiaojuan; Chi, Shuangshuang; Liu, Jinrong; Wang, Ping; Bush, Mark; Benn, Vincent; Yang, Y Fred; Zhang, Jay.

Afiliação

Jaisser F; INSERM UMRS1138, Sorbonne Université, Université de Paris, Centre de Recherche des Cordeliers, Paris, France.
Tan X; KBP BioSciences Co., Ltd., Shandong, China.
Chi S; KBP BioSciences Co., Ltd., Shandong, China.
Liu J; KBP BioSciences Co., Ltd., Shandong, China.
Wang P; KBP BioSciences Co., Ltd., Shandong, China.
Bush M; Nuventra Inc., Durham, NC, United States.
Benn V; KBP BioSciences USA Inc., Princeton, NJ, United States.
Yang YF; KBP BioSciences USA Inc., Princeton, NJ, United States.
Zhang J; KBP BioSciences USA Inc., Princeton, NJ, United States.

Front Pharmacol ; 12: 604928, 2021.

Article em En | MEDLINE | ID: mdl-34248613

Palavras-chave

UACR; hyperkalemia; mineralocorticoid receptor; nephropathy; non-steroidal; therapeutic index; urinary albumin to creatinine ratio

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article