Integration of sleep homeostasis and navigation in Drosophila.
PLoS Comput Biol
; 17(7): e1009088, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-34252086
ABSTRACT
During sleep, the brain undergoes dynamic and structural changes. In Drosophila, such changes have been observed in the central complex, a brain area important for sleep control and navigation. The connectivity of the central complex raises the question about how navigation, and specifically the head direction system, can operate in the face of sleep related plasticity. To address this question, we develop a model that integrates sleep homeostasis and head direction. We show that by introducing plasticity, the head direction system can function in a stable way by balancing plasticity in connected circuits that encode sleep pressure. With increasing sleep pressure, the head direction system nevertheless becomes unstable and a sleep phase with a different plasticity mechanism is introduced to reset network connectivity. The proposed integration of sleep homeostasis and head direction circuits captures features of their neural dynamics observed in flies and mice.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sono
/
Navegação Espacial
/
Homeostase
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article