Your browser doesn't support javascript.
loading
Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations.
Haslam, Danielle E; Peloso, Gina M; Guirette, Melanie; Imamura, Fumiaki; Bartz, Traci M; Pitsillides, Achilleas N; Wang, Carol A; Li-Gao, Ruifang; Westra, Jason M; Pitkänen, Niina; Young, Kristin L; Graff, Mariaelisa; Wood, Alexis C; Braun, Kim V E; Luan, Jian'an; Kähönen, Mika; Kiefte-de Jong, Jessica C; Ghanbari, Mohsen; Tintle, Nathan; Lemaitre, Rozenn N; Mook-Kanamori, Dennis O; North, Kari; Helminen, Mika; Mossavar-Rahmani, Yasmin; Snetselaar, Linda; Martin, Lisa W; Viikari, Jorma S; Oddy, Wendy H; Pennell, Craig E; Rosendall, Frits R; Ikram, M Arfan; Uitterlinden, Andre G; Psaty, Bruce M; Mozaffarian, Dariush; Rotter, Jerome I; Taylor, Kent D; Lehtimäki, Terho; Raitakari, Olli T; Livingston, Kara A; Voortman, Trudy; Forouhi, Nita G; Wareham, Nick J; de Mutsert, Renée; Rich, Steven S; Manson, JoAnn E; Mora, Samia; Ridker, Paul M; Merino, Jordi; Meigs, James B; Dashti, Hassan S.
Afiliação
  • Haslam DE; Nutritional Epidemiology Program (D.E.H., M. Guirette, K.A.L., N.M.M.), Tufts University, Boston, MA.
  • Peloso GM; Channing Division of Network Medicine (D.E.H., J.E.M.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
  • Guirette M; Department of Nutrition (D.E.H.), Harvard T.H. Chan School of Public Health, Boston, MA.
  • Imamura F; Department of Biostatistics, Boston University School of Public Health, MA (G.M.P., A.N.P., J.D.).
  • Bartz TM; Nutritional Epidemiology Program (D.E.H., M. Guirette, K.A.L., N.M.M.), Tufts University, Boston, MA.
  • Pitsillides AN; Medical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., J.L., N.G.F., N.J.W.).
  • Wang CA; Cardiovascular Health Research Unit, Departments of Biostatistics (T.M.B.), University of Washington, Seattle.
  • Li-Gao R; Department of Medicine (T.M.B., R.N.L., B.M.P.), University of Washington, Seattle.
  • Westra JM; Department of Biostatistics, Boston University School of Public Health, MA (G.M.P., A.N.P., J.D.).
  • Pitkänen N; School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, NSW, Australia (C.A.W., C.E.P.).
  • Young KL; Department of Clinical Epidemiology (R.L.G., D.O.M.-K., F.R.R., R.dM.), Leiden University Medical Center, the Netherlands.
  • Graff M; Dordt University, Sioux Center, IA (J.M.W., N.T.).
  • Wood AC; Auria Biobank (N.P.), University of Turku, Finland.
  • Braun KVE; Research Centre of Applied and Preventive Cardiovascular Medicine (N.P., O.T.R.), University of Turku, Finland.
  • Luan J; Department of Epidemiology, Gillings School of Global Public Health (K.L.Y., M. Graff, K.N.), University of North Carolina, Chapel Hill.
  • Kähönen M; Department of Epidemiology, Gillings School of Global Public Health (K.L.Y., M. Graff, K.N.), University of North Carolina, Chapel Hill.
  • Kiefte-de Jong JC; USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX (A.C.W.).
  • Ghanbari M; Department of Epidemiology (K.V.E.B., J.C.K.-d.J., M. Ghanbari, M.A.I.), Erasmus MC University Medical Center Rotterdam, the Netherlands.
  • Tintle N; Medical Research Council Epidemiology Unit, University of Cambridge, United Kingdom (F.I., J.L., N.G.F., N.J.W.).
  • Lemaitre RN; Department of Clinical Physiology (M.K.), Tampere University Hospital, Finland.
  • Mook-Kanamori DO; Department of Clinical Physiology (M.K.), Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Finland.
  • North K; Department of Public Health and Primary Care (J.C.L.d.J., D.O.M.-K.), Leiden University Medical Center, the Netherlands.
  • Helminen M; Department of Epidemiology (K.V.E.B., J.C.K.-d.J., M. Ghanbari, M.A.I.), Erasmus MC University Medical Center Rotterdam, the Netherlands.
  • Mossavar-Rahmani Y; Department of Epidemiology (K.V.E.B., J.C.K.-d.J., M. Ghanbari, M.A.I.), Erasmus MC University Medical Center Rotterdam, the Netherlands.
  • Snetselaar L; Dordt University, Sioux Center, IA (J.M.W., N.T.).
  • Martin LW; Department of Medicine (T.M.B., R.N.L., B.M.P.), University of Washington, Seattle.
  • Viikari JS; Department of Clinical Epidemiology (R.L.G., D.O.M.-K., F.R.R., R.dM.), Leiden University Medical Center, the Netherlands.
  • Oddy WH; Department of Public Health and Primary Care (J.C.L.d.J., D.O.M.-K.), Leiden University Medical Center, the Netherlands.
  • Pennell CE; Department of Epidemiology, Gillings School of Global Public Health (K.L.Y., M. Graff, K.N.), University of North Carolina, Chapel Hill.
  • Rosendall FR; Carolina Center for Genome Science (K.N.), University of North Carolina, Chapel Hill.
  • Ikram MA; Research Development and Innovation Centre (M.H.), Tampere University Hospital, Finland.
  • Uitterlinden AG; Faculty of Social Sciences, Health Sciences, Tampere University, Finland (M.H.).
  • Psaty BM; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.M.-R.).
  • Mozaffarian D; Department of Epidemiology, University of Iowa, Iowa City (L.S.).
  • Rotter JI; George Washington University School of Medicine and Health Sciences, Washington, D.C. (L.W.M.).
  • Taylor KD; Department of Medicine (J.S.V.), University of Turku, Finland.
  • Lehtimäki T; Division of Medicine (J.S.V.), Turku University Hospital, Finland.
  • Raitakari OT; Menzies Institute for Medical Research, University of Tasmania, HOB, Australia (W.H.O.).
  • Livingston KA; Nutrition and Genomics Laboratory (C.E.S.), Tufts University, Boston, MA.
  • Voortman T; School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, NSW, Australia (C.A.W., C.E.P.).
  • Forouhi NG; Department of Clinical Epidemiology (R.L.G., D.O.M.-K., F.R.R., R.dM.), Leiden University Medical Center, the Netherlands.
  • Wareham NJ; Department of Epidemiology (K.V.E.B., J.C.K.-d.J., M. Ghanbari, M.A.I.), Erasmus MC University Medical Center Rotterdam, the Netherlands.
  • de Mutsert R; Department of Internal Medicine (A.G.U.), Erasmus MC University Medical Center Rotterdam, the Netherlands.
  • Rich SS; Department of Medicine (T.M.B., R.N.L., B.M.P.), University of Washington, Seattle.
  • Manson JE; Departments of Epidemiology and Health Services (B.M.P.), University of Washington, Seattle.
  • Mora S; Kaiser Permanente Washington Health Research Institute, Seattle, WA (B.M.P.).
  • Ridker PM; Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, and Friedman School of Nutrition Science and Policy (D.M.), Tufts University, Boston, MA.
  • Merino J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T.).
  • Meigs JB; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T.).
  • Dashti HS; Department of Clinical Chemistry (T.L.), Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Finland.
Circ Genom Precis Med ; 14(4): e003288, 2021 08.
Article em En | MEDLINE | ID: mdl-34270325
BACKGROUND: ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to HDL-C (high-density lipoprotein cholesterol) and triglyceride concentrations. We hypothesized that SSB consumption would modify the association between genetic variants in the CHREBP locus and dyslipidemia. METHODS: Data from 11 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (N=63 599) and the UK Biobank (N=59 220) were used to quantify associations of SSB consumption, genetic variants, and their interaction on HDL-C and triglyceride concentrations using linear regression models. A total of 1606 single nucleotide polymorphisms within or near CHREBP were considered. SSB consumption was estimated from validated questionnaires, and participants were grouped by their estimated intake. RESULTS: In a meta-analysis, rs71556729 was significantly associated with higher HDL-C concentrations only among the highest SSB consumers (ß, 2.12 [95% CI, 1.16-3.07] mg/dL per allele; P<0.0001), but not significantly among the lowest SSB consumers (P=0.81; PDiff <0.0001). Similar results were observed for 2 additional variants (rs35709627 and rs71556736). For triglyceride, rs55673514 was positively associated with triglyceride concentrations only among the highest SSB consumers (ß, 0.06 [95% CI, 0.02-0.09] ln-mg/dL per allele, P=0.001) but not the lowest SSB consumers (P=0.84; PDiff=0.0005). CONCLUSIONS: Our results identified genetic variants in the CHREBP locus that may protect against SSB-associated reductions in HDL-C and other variants that may exacerbate SSB-associated increases in triglyceride concentrations. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00005133, NCT00005121, NCT00005487, and NCT00000479.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Polimorfismo de Nucleotídeo Único / Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos / Bebidas Adoçadas com Açúcar / HDL-Colesterol Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Polimorfismo de Nucleotídeo Único / Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos / Bebidas Adoçadas com Açúcar / HDL-Colesterol Tipo de estudo: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article