Bifunctional modalities for repurposing protein function.

Modell, Ashley E; Lai, Sophia; Nguyen, Tuan M; Choudhary, Amit

Modell, Ashley E; Lai, Sophia; Nguyen, Tuan M; Choudhary, Amit.

Afiliação

Modell AE; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
Lai S; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Nguyen TM; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA.
Choudhary A; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA. Electroni

Cell Chem Biol ; 28(7): 1081-1089, 2021 07 15.

Article em En | MEDLINE | ID: mdl-34270935

Assuntos

Proteínas/metabolismo; Humanos; RNA/metabolismo

Palavras-chave

PROTACs; bifunctional molecules; molecular glues; posttranslational modifications; protein degradation; proximity induction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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