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BI-RADS Ultrasound Lexicon Descriptors and Stromal Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer.
Candelaria, Rosalind P; Spak, David A; Rauch, Gaiane M; Huo, Lei; Bassett, Roland L; Santiago, Lumarie; Scoggins, Marion E; Guirguis, Mary S; Patel, Miral M; Whitman, Gary J; Moulder, Stacy L; Thompson, Alastair M; Ravenberg, Elizabeth E; White, Jason B; Abuhadra, Nour K; Valero, Vicente; Litton, Jennifer; Adrada, Beatriz E; Yang, Wei T.
Afiliação
  • Candelaria RP; Department of Breast Imaging, Unit 1350, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: rcandelaria@mdanderson.org.
  • Spak DA; Department of Breast Imaging, Unit 1350, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Rauch GM; Department of Breast Imaging, Unit 1350, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Huo L; Department of Pathology, Unit 085, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Bassett RL; Department of Biostatistics, Unit 1411, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Santiago L; Department of Breast Imaging, Unit 1350, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Scoggins ME; Department of Breast Imaging, Unit 1350, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Guirguis MS; Department of Breast Imaging, Unit 1350, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Patel MM; Department of Breast Imaging, Unit 1350, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Whitman GJ; Department of Breast Imaging, Unit 1350, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Moulder SL; Department of Breast Medical Oncology, Unit 1354, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Thompson AM; Department of Breast Surgical Oncology, Unit 1434, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Ravenberg EE; Department of Breast Medical Oncology, Unit 1354, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • White JB; Department of Breast Medical Oncology, Unit 1354, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Abuhadra NK; Department of Breast Medical Oncology, Unit 1354, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Valero V; Department of Breast Medical Oncology, Unit 1354, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Litton J; Department of Breast Medical Oncology, Unit 1354, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Adrada BE; Department of Breast Imaging, Unit 1350, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Yang WT; Department of Breast Imaging, Unit 1350, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Acad Radiol ; 29 Suppl 1: S35-S41, 2022 01.
Article em En | MEDLINE | ID: mdl-34272161
PURPOSE: Increased levels of stromal tumor-infiltrating lymphocytes (sTILs) have recently been considered a favorable independent prognostic and predictive biomarker in triple-negative breast cancer (TNBC). The purpose of this study was to determine the relationship between BI-RADS (Breast Imaging Reporting and Data System) ultrasound lexicon descriptors and sTILs in TNBC. MATERIALS AND METHODS: Patients with stage I-III TNBC were evaluated within a single-institution neoadjuvant clinical trial. Two fellowship-trained breast radiologists used the BI-RADS ultrasound lexicon to assess pretreatment tumor shape, margin, echo pattern, orientation, posterior features, and vascularity. sTILs were defined as low <20 or high ≥20 on the pretreatment biopsy. Fisher's exact tests were used to assess the association between lexicon descriptors and sTIL levels. RESULTS: The 284 patients (mean age 52 years, range 24-79 years) were comprised of 68% (193/284) with low-sTIL tumors and 32% (91/284) with high-sTIL tumors. TNBC tumors with high sTILs were more likely to have the following features: (1) oval/round shape than irregular shape (p = 0.003), (2) circumscribed or microlobulated margins than spiculated, indistinct, or angular margins (p = 0.0005); (3) complex cystic and solid pattern than heterogeneous pattern (p = 0.006); and (4) posterior enhancement than shadowing (p = 0.002). There was no significant association between sTILs and descriptors for orientation and vascularity (p = 0.06 and p = 0.49, respectively). CONCLUSION: BI-RADS ultrasound descriptors of the pretreatment appearance of a TNBC tumor can be useful in discriminating between tumors with low and high sTIL levels. Therefore, there is a potential use of ultrasound tumor characteristics to complement sTILs when used as stratification factors in treatment algorithms for TNBC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Neoplasias de Mama Triplo Negativas Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Neoplasias de Mama Triplo Negativas Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article