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System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2.
Vicenti, Ilaria; Martina, Maria Grazia; Boccuto, Adele; De Angelis, Marta; Giavarini, Giorgia; Dragoni, Filippo; Marchi, Serena; Trombetta, Claudia Maria; Crespan, Emmanuele; Maga, Giovanni; Eydoux, Cecilia; Decroly, Etienne; Montomoli, Emanuele; Nencioni, Lucia; Zazzi, Maurizio; Radi, Marco.
Afiliação
  • Vicenti I; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • Martina MG; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Viale delle Scienze, 27/A, 43124, Parma, Italy.
  • Boccuto A; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • De Angelis M; Department of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
  • Giavarini G; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Viale delle Scienze, 27/A, 43124, Parma, Italy.
  • Dragoni F; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • Marchi S; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
  • Trombetta CM; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
  • Crespan E; Istituto di Genetica Molecolare, IGM-CNR "Luigi Luca Cavalli-Sforza", Via Abbiategrasso 207, 27100, Pavia, Italy.
  • Maga G; Istituto di Genetica Molecolare, IGM-CNR "Luigi Luca Cavalli-Sforza", Via Abbiategrasso 207, 27100, Pavia, Italy.
  • Eydoux C; AFMB, CNRS, Université Aix-Marseille, UMR 7257, Marseille, France.
  • Decroly E; AFMB, CNRS, Université Aix-Marseille, UMR 7257, Marseille, France.
  • Montomoli E; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy; VisMederi s.r.l, Strada del Petriccio e Belriguardo 35, 53100 Siena, Italy.
  • Nencioni L; Department of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
  • Zazzi M; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
  • Radi M; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Viale delle Scienze, 27/A, 43124, Parma, Italy. Electronic address: marco.radi@unipr.it.
Eur J Med Chem ; 224: 113683, 2021 Nov 15.
Article em En | MEDLINE | ID: mdl-34273661
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Orthomyxoviridae / Purinas / Flavivirus / SARS-CoV-2 Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Orthomyxoviridae / Purinas / Flavivirus / SARS-CoV-2 Idioma: En Ano de publicação: 2021 Tipo de documento: Article