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Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds with a Multifunctional Wound Dressing.
Atashgah, Rahimeh B; Ghasemi, Amir; Raoufi, Mohammad; Abdollahifar, Mohammad-Amin; Zanganeh, Steven; Nejadnik, Hossein; Abdollahi, Alieh; Sharifi, Shahriar; Lea, Baltazar; Cuerva, Miguel; Akbarzadeh, Mehdi; Alvarez-Lorenzo, Carmen; Ostad, Seyed Nasser; Theus, Andrea S; LaRock, Doris L; LaRock, Christopher N; Serpooshan, Vahid; Sarrafi, Rouzbeh; Lee, Ki-Bum; Vali, Hojatollah; Schönherr, Holger; Gould, Lisa; Taboada, Pablo; Mahmoudi, Morteza.
Afiliação
  • Atashgah RB; Colloids and Polymers Physics Group, Particle Physics Department, Faculty of Physics and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
  • Ghasemi A; Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14167-53955, Iran.
  • Raoufi M; Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 13169-43551, Iran.
  • Abdollahifar MA; Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 13169-43551, Iran.
  • Zanganeh S; Physical Chemistry I, Department of Chemistry and Biology & Research Center of Micro and Nanochemistry and Engineering (Cµ), University of Siegen, Siegen 57076, Germany.
  • Nejadnik H; Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19395-4719, Iran.
  • Abdollahi A; Department of Bioengineering, University of Massachusetts Dartmouth, Dartmouth, Massachusetts 02747, United States.
  • Sharifi S; Department of Radiology, University of Pennsylvania, Philladelphia, Pennsylvania 19104, United States.
  • Lea B; Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14167-53955, Iran.
  • Cuerva M; Precision Health Program, Michigan State University, East Lansing, Michigan 48824, United States.
  • Akbarzadeh M; Colloids and Polymers Physics Group, Particle Physics Department, Faculty of Physics and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
  • Alvarez-Lorenzo C; NANOMAG Group, Technological Research Institute (IIT), Physical Chemistry Department, University of Santiago de Compostela (USC), Santiago de Compostela 15782, Spain.
  • Ostad SN; Sadra Wound, Ostomy and Osteomyelitis Specialist Center, Tehran, Iran.
  • Theus AS; R+D Pharma Group, Pharmacology, Pharmacy and Pharmaceutical Technology Department, Faculty of Pharmacy and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
  • LaRock DL; Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14167-53955, Iran.
  • LaRock CN; Wallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, Georgia 30322, United States.
  • Serpooshan V; Department of Microbiology and Immunology, Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
  • Sarrafi R; Department of Microbiology and Immunology, Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
  • Lee KB; Wallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, Georgia 30322, United States.
  • Vali H; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30309, United States.
  • Schönherr H; Children's Healthcare of Atlanta, Atlanta, Georgia 30322, United States.
  • Gould L; SciDerm, Natick, Massachusetts United States.
  • Taboada P; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States.
  • Mahmoudi M; Department of Anatomy and Cell Biology and Facility for Electron Microscopy Research, McGill University, Montreal, Quebec H3A 0C3, Canada.
Mol Pharm ; 18(8): 3171-3180, 2021 08 02.
Article em En | MEDLINE | ID: mdl-34279974
ABSTRACT
Current treatment of chronic wounds has been critically limited by various factors, including bacterial infection, biofilm formation, impaired angiogenesis, and prolonged inflammation. Addressing these challenges, we developed a multifunctional wound dressing-based three-pronged approach for accelerating wound healing. The multifunctional wound dressing, composed of nanofibers, functional nanoparticles, natural biopolymers, and selected protein and peptide, can target multiple endogenous repair mechanisms and represents a promising alternative to current wound healing products.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Infecções Estafilocócicas / Staphylococcus aureus / Bandagens / Cicatrização / Infecção dos Ferimentos / Anexina A1 / Proteínas Relacionadas à Folistatina / Diabetes Mellitus Experimental / Ferida Cirúrgica Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Infecções Estafilocócicas / Staphylococcus aureus / Bandagens / Cicatrização / Infecção dos Ferimentos / Anexina A1 / Proteínas Relacionadas à Folistatina / Diabetes Mellitus Experimental / Ferida Cirúrgica Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article