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Epithelial-to-Mesenchymal Transition and Neoangiogenesis in Laryngeal Squamous Cell Carcinoma.
Franz, Leonardo; Nicolè, Lorenzo; Frigo, Anna Chiara; Ottaviano, Giancarlo; Gaudioso, Piergiorgio; Saccardo, Tommaso; Visconti, Francesca; Cappellesso, Rocco; Blandamura, Stella; Fassina, Ambrogio; Marioni, Gino.
Afiliação
  • Franz L; Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 35128 Padova, Italy.
  • Nicolè L; Ulss3 Serenissima, Unit of Surgical Pathology & Cytopathology, Ospedale dell'Angelo, 30174 Mestre, Italy.
  • Frigo AC; Unit of Pathology & Cytopathology, Department of Medicine (DIMED), University of Padova, 35121 Padova, Italy.
  • Ottaviano G; Department of Cardiac-Thoracic-Vascular Sciences and Public Health, Padova University, 35128 Padova, Italy.
  • Gaudioso P; Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 35128 Padova, Italy.
  • Saccardo T; Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 35128 Padova, Italy.
  • Visconti F; Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 35128 Padova, Italy.
  • Cappellesso R; Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 35128 Padova, Italy.
  • Blandamura S; Department of Medicine (DIMED), Section of Pathological Anatomy, University of Padova, 35121 Padova, Italy.
  • Fassina A; Department of Medicine (DIMED), Section of Pathological Anatomy, University of Padova, 35121 Padova, Italy.
  • Marioni G; Unit of Pathology & Cytopathology, Department of Medicine (DIMED), University of Padova, 35121 Padova, Italy.
Cancers (Basel) ; 13(13)2021 Jul 03.
Article em En | MEDLINE | ID: mdl-34283055
ABSTRACT
The mechanism of epithelial-mesenchymal transition (EMT) is fundamental for carcinogenesis, tumor progression, cancer cell invasion, metastasis, recurrence, and therapy resistance, comprising important events, such as cellular junction degradation, downregulation of epithelial phenotype markers, overexpression of mesenchymal markers, and increase in cellular motility. The same factors that drive epithelial cells toward a mesenchymal phenotype may also drive endothelial cells toward a proangiogenic phenotype. The aim of this exploratory study was to investigate a potential interplay between EMT and angiogenesis (quantified through CD105 expression) in laryngeal carcinoma (LSCC). CD105-assessed microvessel density (MVD) and EMT markers (E-cadherin, N-cadherin, Snail, Slug, Zeb1, and Zeb2) were assessed on 37 consecutive LSCC cases. The univariate Cox regression model identified pN+ status (p = 0.0343) and Slug expression (p = 0.0268) as predictive of disease-free survival (DFS). A trend toward significance emerged for CD105-assessed MVD (p = 0.0869) and N-cadherin expression (p = 0.0911). In the multivariate Cox model, pN-status, Slug, and N-cadherin expressions retained their significant values in predicting DFS (p = 0.0346, p = 0.0430, and p = 0.0214, respectively). Our data support the hypothesis of a mutual concurrence of EMT and angiogenesis in driving LSCC cells toward an aggressive phenotype. To better characterize the predictive performance of prognostic models based on EMT and angiogenesis, further large-scale prospective studies are required.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article