Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins.

Nowicka, Urszula; Chroscicki, Piotr; Stroobants, Karen; Sladowska, Maria; Turek, Michal; Uszczynska-Ratajczak, Barbara; Kundra, Rishika; Goral, Tomasz; Perni, Michele; Dobson, Christopher M; Vendruscolo, Michele; Chacinska, Agnieszka

Nowicka, Urszula; Chroscicki, Piotr; Stroobants, Karen; Sladowska, Maria; Turek, Michal; Uszczynska-Ratajczak, Barbara; Kundra, Rishika; Goral, Tomasz; Perni, Michele; Dobson, Christopher M; Vendruscolo, Michele; Chacinska, Agnieszka.

Afiliação

Nowicka U; ReMedy International Research Agenda Unit, University of Warsaw, Warsaw, Poland.
Chroscicki P; Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Stroobants K; IMol Polish Academy of Sciences, Warsaw, Poland.
Sladowska M; Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Turek M; International Institute of Molecular and Cell Biology, Warsaw, Poland.
Uszczynska-Ratajczak B; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Kundra R; Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Goral T; International Institute of Molecular and Cell Biology, Warsaw, Poland.
Perni M; ReMedy International Research Agenda Unit, University of Warsaw, Warsaw, Poland.
Dobson CM; Centre of New Technologies, University of Warsaw, Warsaw, Poland.
Vendruscolo M; International Institute of Molecular and Cell Biology, Warsaw, Poland.
Chacinska A; Centre of New Technologies, University of Warsaw, Warsaw, Poland.

Elife ; 102021 07 20.

Article em En | MEDLINE | ID: mdl-34292154

Assuntos

Doença de Alzheimer/metabolismo; Citosol/metabolismo; Mitocôndrias/metabolismo; Proteínas Mitocondriais/metabolismo; Agregados Proteicos; Proteostase; Proteínas de Saccharomyces cerevisiae/metabolismo; Saccharomyces cerevisiae/metabolismo; Doença de Alzheimer/genética; Animais; Caenorhabditis elegans/genética; Caenorhabditis elegans/metabolismo; Proteínas de Caenorhabditis elegans/genética; Proteínas de Caenorhabditis elegans/metabolismo; Bases de Dados Genéticas; Proteínas de Choque Térmico/genética; Proteínas de Choque Térmico/metabolismo; Humanos; Mitocôndrias/genética; Proteínas Mitocondriais/genética; Chaperonas Moleculares/genética; Chaperonas Moleculares/metabolismo; Transporte Proteico; Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/genética

Palavras-chave

C. elegans; S. cerevisiae; aggregation; biochemistry; chaperones; chemical biology; homeostasis; metastable proteins; mitochondria; neurodegeneration

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Citosol / Proteínas de Saccharomyces cerevisiae / Proteínas Mitocondriais / Doença de Alzheimer / Agregados Proteicos / Proteostase / Mitocôndrias Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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