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AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B.
Xu, Jia; Yu, Xufen; Martin, Tiphaine C; Bansal, Ankita; Cheung, Kakit; Lubin, Abigail; Stratikopoulos, Elias; Cahuzac, Kaitlyn M; Wang, Li; Xie, Ling; Zhou, Royce; Shen, Yudao; Wu, Xuewei; Yao, Shen; Qiao, Ruifang; Poulikakos, Poulikos I; Chen, Xian; Liu, Jing; Jin, Jian; Parsons, Ramon.
Afiliação
  • Xu J; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Yu X; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Martin TC; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Bansal A; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Cheung K; Mount Sinai Center for Therapeutics Discovery, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Lubin A; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Stratikopoulos E; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Cahuzac KM; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Wang L; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Xie L; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Zhou R; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Shen Y; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Wu X; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Yao S; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Qiao R; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Poulikakos PI; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Chen X; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Liu J; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • Jin J; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
  • Parsons R; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Cancer Discov ; 11(12): 3064-3089, 2021 12 01.
Article em En | MEDLINE | ID: mdl-34301793
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-akt / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-akt / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article